| Objective: To investigate the positive distribution of antinuclear antibody(ANA)in healthy subjects tested in the physical examination center of the affiliated hospital of the Zunyi medical university.To investigate the correlation between positive autoantibody of the newly treated pulmonary tuberculosis patients and the healthy volunteers.Methods: From May 2016 to May 2018,a total of 57,145 medical subjects were collected from the physical examination center of the affiliated hospital of the Zunyi medical university.Venous blood was collected in the morning and serum ANA was detected by indirect immunofluorescence method.The indicators in this group were fluorescence model and titer of ANA.A total of 96 initially treated tuberculosis patients and 174 healthy volunteers were collected from July 2016 to December 2016.Serum autoantibodies [ANA,antinuclear antibody spectrum(ANAs),rheumatoid factor(RF),anti-cyclocitrulline peptide antibody(ACCP),and anti-neutrophil cytoplasmic antibodies were collected after morning venous blood collection for detect ion.ANCA)] to explore the positive rates of the two groups and compare the differences of indicators between each group.(2)Compared with the positive rate of ANA positive women of all ages in all female examinees and male ANA positive men of all ages in all male examinees,Results: 1.Distribution of ANA among the physical examination population in compliance hospital :(1)there were 57,145 healthy physical examination patients(42,154 males and 14,991 females),and 5497 positive ANA patients(3,152 males and 2,345 females).Male positive rate accounted for 5.52% of all the subjects,and female positive rate accounted for 4.10% of all the subjects;Because of the large difference in the total number of men and women taking medical examinations,separate statistics were carried out.The ANA positive rate of male was 7.48%,and that of female was 15.64%.The ANA positive rate of female was significantly higher than that of male,and the difference was statistically significant.ANA positive rates were higher in women aged 21-30,31-40,41-50,51-60,61-70,71-80 and 81-90 than in men of the same age group,and the differences were statistically significant.The ANA positive rate of men aged 11-20 years was higher than that of women of the same age group,but the difference was not statistically significant.Among all age groups,the positive rate of female ANA among all female subjects was the highest in the 71-80 years old(37.70%),and the lowest in the 11-20 years old(4.35%).The male ANA positive rate was the highest in the 81-90 age group(21.28%),and the lowest in the 21-30 age group(3.98%).(3)Low titer positive rate(ANA titer < 1:320): the highest rate was found in the 31-40 age group,accounting for 86.43% of all low titer positive rates.The difference was statistically significant.High titer positive rate(ANA titer ≥ 1:320): it was highest in the 81-90 age group,accounting for 34.74% of all ANA high titer positive rates,with statistically significant difference.2.The RF,ANA and ANAs positive rates in the tuberculosis group were higher than those in the healthy group compared with the 96 newly treated tuberculosis patients hospitalized in compliance affiliated hospital and 174 healthy volunteers,and the difference was statistically significant.Conclusion: The overall ANA positive rate of the physical examination population in the First Affiliated Hospital of Zunyi Medical University was 9.62%,the male ANA positive rate was 7.48%,the female ANA positive rate was 15.64%,the female ANA positive rate was higher than the male.In ANA positive,nuclear particle type was the main fluorescence karyotype.In 31-40 years old,ANA was mainly low titer,while in 81-90 years old,ANA was mainly high titer.The positive rates of ANA,ANAs and RF of newly treated tuberculosis in our hospital were higher than those of healthy control group. |
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