| Objective To investigate the changes of plasma omentin levels in type 2 diabetes mellitus (T2DM) and during the treatment of Liraglutide.Methods 1.Plasma omentin levels were measured by an ELISA in patients with T2DM and normal controls. The relationship between omentin levels and BMI, WHR, HOMA-IR, HOMA-IS, FFA were also analyzed. 2.After Liraglutide treatment, the changes of plasma omentin levels were observed in patients with T2DM.Results 1.Fasting plasma omentin levels were lower in T2DM patients compared with normal controls (19.3±3.9 vs. 26.4±6.0 ug/L, P<0.01). Fasting plasma levels in T2DM patients were correlated negatively with FINS, HOMA-IR(r=-0.41,P<0.05 and r=-0.56, P<0.01). 2. After Liraglutide treatment in type 2 diabetes mellitus , WHR, BMI, FPG, 2hPPG and HbA1c were significantly decreased (all P<0.01), and HOMA-IS levels were significantly increased (P<0.01). Interestingly, plasma omentin levels were also significantly increased after treated by Liraglutide (19.3±3.9 vs. 21.2±3.8μg/L, P<0.01).Conclusion 1.Omentin is one of the adipocytokines which is related to IR and diabetes. 2.Liraglutide can remarkably improve glucose metabolism and insulin sensitivity, and also increase plasma omentin levels.
|
PDF Full Text Request