The Correlation Analysis Between CIMT In Patients With Type 2 Diabetes Mellitus And Omentin-1 And Visfatin And Glutamul Transpeptidase

Objective:Serum levels of omentin-1,visfatin,glutamyl transpeptidase(GGT)and carotid intima media thickness(CIMT)were measured in patients with type 2 diabetes mellitus(T2DM),to explore the correlation between serum omentin-1,visfatin,GGT and CIMT in patients with T2 DM,the risk factors affecting CIMT,and to provide detection methods for clinical diagnosis and disease diagnosis and treatment.Methods:From November 1,2018 to June 30,2019,116 T2 DM patients in the endocrine department of our hospital were collected,according to CIMT,it can be divided into the thickening group(CIMT≥0.9mm,n=58)and the non thickening group(CIMT<0.9mm,n=58).The general data of the two groups of subjects were recorded,including: age,gender,height,weight,systolic blood pressure(SBP),diastolic blood pressure(DBP),calculated the body mass index(BMI)by dividing the weight by the square of height,measured the glycosylated hemoglobin(hemoglobin A1 c,Hb Alc),fasting blood glucose(FBG),2-hour postprandial blood glucose(2h PG),high-density lipoprotein cholesterol(HDL-C),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),total triglyceride(TG),fasting C-peptide and C-peptide at 2 hours after meal,detected the GGT in biochemical items,measured CIMT.Detection of serum omentin-1 and visfatin by enzyme linked immunosorbent assay(ELISA).The differences of clinical indexes between the two groups were compared.The correlation between CIMT,omentin-1,visfatin and GGT was analyzed.Age,omentin-1 and visfatin were used as independent variables,whether CIMT thickened or not was used as dependent variable,realized the influencing factors of CIMT.Results:1.Comparison of two groups of general information and test data1.1 There were no significant differences between the two groups of subjects in general information(height,weight,gender,BMI,SBP,DBP)(P>0.05);see Table 1.There were no significant differences among the two groups in test data(FBG,2h PG,Hb A1 c,TC,LDL-C,HDL-C,TG,fasting C-peptide,C-peptide at 2 hours after meal,GGT)(P>0.05);see Table 2.1.2 Compared with the thickening group,the age in the non thickening group was lower,the difference was statistically significant(P<0.05);see Table 1.1.3 Compared with the thickening group,in the non thickening group,CIMT and the content of visfatin decreased,while the content of omentin-1 increased,the differences were statistically significant(P<0.05);see Table 2.2.Correlation analysis results of CIMT in type 2 diabetic patients with omentin-1,visfatin and GGTCIMT has a positive correlation with visfatin and a negative correlation with omentin-1.There was no correlation between CIMT and GGT.3.Correlation analysis results of omentin-1 and visfatin in type 2 diabetic patientsThere is a negative correlation between omentin-1 and visfatin.4.Logistic regression analysis was performed for the influenced factors of CIMT in type 2 diabetic patientsWhether CIMT thickened or not was used as dependent variable,age, omentin-1 and visfatin were used as independent variables,carried out logistic regression analysis.The results showed that: visfatin was an independent risk factor for CIMT thickened in type 2 diabetic patients;see Table 3.Conclusion:1.CIMT in type 2 diabetic patients has a positive correlation with visfatin and a negative correlation with omentin-1.2.Visfatin was an independent risk factor for CIMT thickened in type 2 diabetic patients.3.There is a negative correlation between omentin-1 and visfatin.4.There was no correlation between GGT and CIMT in type 2 diabetic patients.