Clinical Research On Dialectical Classify Treatments Of TCM For ICU Antibiotic-associated Diarrhea

Objective:To evaluate the clinical effectiveness of dialectical classify treatments of TCM in treating antibiotic associated diarrhea (AAD), we can formulate TCM dialectical therapy antibiotics-associated diarrhea's "standard operating procedures".Methods:By the means of multi center controlled trial, we have collected 90 cases of antibiotic-associated diarrhea,45cases for the treatment group and the control group respectively from January 2009 to June 2010 in Chengdu University of Traditional Chinese Medicine Hospital ICU, The Third People.s Hospital of Chengdu City ICU,Panzhihua Hospital of Traditional Chinese and Western Medicine RICU. Among the treatment groups, Wei Guan Jian was applied to patients with kidney-spleen yang-deficiency pattern, Ren Shen Bai Du San was administrated orally to patients with patterns of wind-dampness struggle and pathogen invasion due to weak healthy qi. Metronidazole and Bifidobacterium were applied in the control group. The treatment course of both groups were 5 days. By observing the 2 groups of patients with diarrhea extent points,diarrhea symptom points,Stool bacillus coccus ratios and comprehensive effects to evaluate the clinical effectiveness of pattern identification of Chinese medicine in treating AAD.Results:(1)Compared with the drug treatment effect-acting period of control group patients, the TCM differentiation treat shorten the duration of symptoms(P<0.01).(2)Both the traditional Chinese medicine dialectical therapy and the modern medicine have improved diarrhea degree integral, but the treatment group was superior to the control group after 3 days, it was statistically significant (P<0.01). (3)Traditional Chinese medicine and modern medicine dialectical therapy both have improved symptom scores, The treatment group was superior to the control group after 2 days, it was statistical significant (P<0.05).(4)Stool bacillus coccus ratios comparison:The two groups both improved the ratios, In the different times, there were not statistically significant differences (P>0.05).(5)The comprehensive effect comparison:the treatment group was 86.6%. the control was 59.1%. By statistical processing, there was statistically significant differences (P<0.01).(6)Safety analysis:two groups did not appear adverse drug reaction.Conclusion:Compared with the western medicine control group, dialectical classify treatments of TCM had a better treatment on antibiotic-associated diarrhea (AAD).It is worth of popularization.