Clinical Research On Combining Traditional Chinese And Western Medicine Treatment Of Idiopathic Membranous Nephropathy

ObjectivesIdiopathic membranous nephropathy elderly primary nephrotic syndrome is more familiar pathological type, but the membranous nephropathy immune suppression therapy process more adverse reactions, and the recurrence rate is high. This topic prospectively observe the clinical curative effect in the process of integration of traditional and western medicine treatment of idiopathic membranous nephropathy, the effect in alleviating the adverse reactions caused by hormones and cytotoxic class immunosuppressive drugs, and safety problems.MethodsCases included in this topic come from nephrology ward or outpatient clinic in guangdong hospital of traditional Chinese medicine, according to the unified diagnostic criteria, the inclusion criteria, exclusion standard, decide 30 cases of qualified, using the method of before and after contrast, gived western medicine basic therapy (hormones and immunosuppression, diuresis detumescence, lipid-lowering, improving high pour-point state, etc), at the same time, and gived the treatment of TCM according to syndrome differentiation, six months for a period of treatment. Observe the changes of clinical symptoms during the course in before and after treatment,24-hour urinary protein quantitative, serum albumin, cholesterol and triglycerides, fibrinogen and so on;at the same time, observe adverse reactions and repeated situation in the healing process.Result 30 patients, completely ease five people, accounted for 16.67%, part catabatic 23, accounted for 76.67%, the total effective rate was 93.34%, Invalid 2, accounting for 6.66% prior. After treatment, the patient edema, dropsy and cadaverous complexion, chills limb swelling of cold, waist knees ache, Leonard stay, loose stools, mouth GanYan dryness, brothers heart heat, less gas fatigue, easy to cold, pale symptoms such as unsophisticated improved (waist knees ache, less gas fatigue P<0.05, and the rest of the symptoms P<0.01), tired symptoms change is not obvious (P>0.05).Six months after treatment, total urinary protein significantly lower (P<0.01), serum albumin significantly increased (P<0.01), TC,TG,LDL-C,FIB dropped significantly (P<0.01). After treatment, leukocytes, liver and kidney function, potassium, defecate characters did not see abnormalities (leukocytes, cereal third transaminase, aspertate aminotransferase, potassium P>0.05, creatinine decline than before P<0.01). In the healing process,1 case for being upper respiratory tract infection and repeated, accounting for 3.33%; 2 cases with lung infection, accounted for 6.67% prior, after treatment, symptoms disappear, and continue into the study. Did not see hormones and cytotoxic or of immunosuppressant other serious adverse reactions.ConclusionCombining traditional Chinese and western medicine treatment of idiopathic membranous nephropathy exactly has the clinical curative effect, can improve membranous nephropathy et the clinical symptoms and signs, improve the clinical response rate, reduce the 24-hour urinary protein quantitative, increase the plasma albumin, lower blood fat, improve blood high pour-point condition, reduce corticosteroids and cytotoxic or immunosuppressive drugs adverse reactions. This treatment gives a full play in traditional Chinese and western medicine treatment of idiopathic membranous nephropathy advantages, has a high clinical value and deserves further research and extension.