| Objective:To analyze the clinical efficacy of combined therapy of Chinese and Western medicine in idiopathic membranous glomerulopathy treatment in 2nd and 8th nephrology departments at our hospital via retrospective analysis,and to preliminarily investigate the effective plan in treating idiopathic membranous glomerulopathyMethod:The information from patients with definite diagnosis of idiopathic membranous glomerulopathy in 2nd and 8th nephrology departments at Heilongjiang TCM hospital was collected.A total of 81 patients with inclusion criteria was recruited from out-patient and in-patient.Then clinical laboratory statistics,pathological type,syndrome differentiation as well as diagnostic and therapeutic condition were concluded,and statistical methods were applied to analyze the data.Result:In 81 idiopathic membranous glomerulopathy patients,the sex ratio was 1.07:1 and the average onset age was 45.91±10.87.During disease onset,there were 51 cases of NS(62.96%)and 28 cases of chronic nephritic syndrome(34.57%).By TCM diagnosis,there were 64.2% of edema and 29.6% of turbid urine.By syndrome differentiation,there were 74.1% of spleen-kidney deficiency,14.8% of qi-yin deficiency and 11.1% of liver-kidney deficiency.Stage II membranous nephropathy was the most commone pathological stage with 51 cases,which took up 63% among all patients.Relevant laboratory examination: statistical significance was found in 24 h urine protein quantitation before treatment(4.71±2.76,g/d)and after treatment(1.48±1.53,g/d).Statistical significance was found in total plasma protein,serum albumin,urine analysis,qualitative urinary protein in sediments and clinical syndrome scores before treatment and after treatment.No statistical significance was found in total cholesterol,triglyceride,serum creatine and GFR before and after treatment.There were 24 cases of complete remission(29.6%),45 cases of partial remission(55.6%),69 cases of overall remission rate(85.2%)and 12 cases of ineffective treatment(14.8%).Conclusion:The majority of idiopathic membranous glomerulopathy seeking treatment to the 2nd and 8th nephrology departments at our hospital was male.Peak period of disease onset age ranged from 35 to 55,mainly with stage II membranous nephropathy.The most selected therapeutic plan and the highest overall remission rate were found in the combination of TCM decoction,hormone and cyclophosphamide;favorable clinical efficacy was also found in combining hormone and tripterygium glycosides.Edema and turbid ruein were mostly diagnosed by TCM,spleen-kidney deficiency and dampness-heat retention were the most commone syndrome differentiation.Self-made Shenyanxiaobai is an effective decoction in treating these types ofTCM syndromes. |
