Establishment Of Dog Model With Chronic Gastritis Belonging To Type Of Deficiency-cold Of Spleen And Effect Of EA Treatment

Chronic gastritis is a common disease of digestive system, supposed to be caused by repeated invasion of different kinds of pathological factors,With catarrh or atropHy mostly limited on gastric mucosa as pathological changes. TCM has aecumulated rich experience in treatment of chronic gastritis by using acupuncture amid improved knowledge on pathogenesis of the disease over years.In this study, Gastritis of Deficiency Cold in the Spleen and Stomach model was established in dogs by synthetical method for two monthes.When the model was established successfully. Except normal control group and model control group,others dogs were treated with Zusanli (ST-36), Nei Guan(PC-6),Wei Shu(BL-21) for 4 weeks. Blood samples of cepHalic venous were collect to detect hematology and biochemistry-Weight changes,clinical symptoms and pathological changes,PH value,pepsin activity Were observed during treatment to determine efficacy of electroacupuncture on chronic gastritis in dogs.Fifteen mongrel dogs weighing betweenlO and 15kg were randomly divided into three groups:normal control group,model control group,EA group, Except normal control group,Chronic Gastritis model of Deficiency Cold in the Spleen and Stomach was established in other dogs by synthetical method:sodium salicylic was given once a day, and ammonia was drink freely etal,all the factors were given for two monthes.When the model was established successfully,Compared with the common control group, model control group turned to be loose stool,anorexia,,action retardation,the frequency of activity draw down,,dispirited, thin and loose clothing hair,less burnish, The weight of dogs lessen obviously, WBC,RBC,HCT,LYM,TP,GLU in the model control group were significantly lower (P<0.05), AST,ALT,ALP were higher (P<0.05),gastric juice PH was significantly higher(P<0.01),pepsin activity was lower (P<0.01)When the model of Chronic Gastritis of Deficiency Cold in the Spleen and Stomach was established successfully in dogs,Except normal control group and model control group,others dogs were treated with Zusanli (ST-36),Nei Guan(PC-6),Wei Shu(BL-21) for 4 weeks After EA treatment for four weeks, Compared to model group, WBC,RBC,HCT,LYM,TP,GLU in the model control group was significantly higher, AST,ALT,ALP was lower (P<0.05),gastric juice PH,the quantity of histamine was significantly lower,pepsin activity was higher (P<0.01)In conclusion, The animal model of chronic gastritis can be induced by synthetical method successfully. The symptoms of chronic gastritis were alleviated effectively by EA.