The Pre-and Postoperative Change Of Th1/Th2 And Th17 On The Cellular Immune Function In Peripheral Blood Of NSCLC Patients

Objective:To study the pre-and postoperative change of T helper cells subsets on the cellular immune function in peripheral blood of patients with non-small cell lung cancer and their clinical significance. Methods:The levels of peripheral blood T helper cells subsets were examined in 27 patients with lung cancer on 3 days before operation and the 14th after operation by flow cytometric analysis. Results:1) The change of Thl cells:After operation, the levels of Thl were higher than that in preoperative, but the change were no statistical significance (23.467±10.343/27.911±7.063,t=-1.609, P> 0.05).2) The change of Th2 cells:The levels of Th2 in postoperative group were significantly lower than that in preoperative (22.16%±9.98%/12.39%±7.84%,t=4.111, P <0.01).3) The change of Thl/Th2:Thl/Th2 in postoperative group were significantly higher than that in preoperative (5.443±13.255/1.579±1.438, Z=-2.583, P<0.05).4) The change of Th17 cells:The levels of Thl7 in postoperative group were significantly lower than that in preoperative (1.68%±1.10%/1.12%±0.46%,t=2.645, P<0.05).5) The change of Th/CD4+:The change of Th/CD4+T before and after operation were no statistical significance (47.304±10.524/42.859±10.290,t=1.41, P>0.05). Conclusion:1) These data suggested that Patients with non-small cell lung cancer had immunity disorder before operation.2) Radical operation could free them from immunosuppression.3) Th17 cells could promote the occurrence of lung cancer.