Study Relationship Between TCM Differentiation Syndromes Of Coronary Heart Disease Patients And Serum NO And Plasma ET

Background:The endothelium plays a central role in maintaining cardiovascular homeostssis via the production and release of nitric oxide(NO) and endothelium(ET), the former is a vascular dilation cytokine, whereas the latter is a vascular constriction one. Extensive researches have demonstrated that vascular endothelium dysfunction was closely related to the pathogenesis of coronary heart disease(CHD). Disbalance of NO and ET may lead to spasm, even thrombogenesis in the coronary artery. We speculate that there are also some rules and correlations between traditional Chinese medicine(TCM) syndromes of CHD and, serum NO and plasma ET levels. However, published literatures on TCM syndromes have not illustrated the relationship of serum levels of NO and ET in various TCM syndromes. Therefore, a further and more comprehensive research is necessary. The result will help clinical doctors commanding the regulation of CHD syndrome differentiation and therapeutic determination, and it could supply objective clinical materials for the standardization of TCM syndrome in CHD.Objective:The experiment was designed to investigate the relationship between serum NO, plasma ET and syndrome differentiation in TCM of CHD, thus to provide an objective proof for syndrome differentiation of TCM.Methods:165 patients with CHD were divided into 6 groups, according to heart blood stasis, retention of phlegm in heart vessel, stagnation of qi due to cold, heart-kidney yin deficiency, dual deficiency of qi and yin, dual deficiency yang and qi.30 members of the control group were randomly selected from the medical center. The level of NO and ET was detected.Results:â‘ The level of NO decreased significantly in patients of CHD compared to those in the control group, while the level of ET increased.â‘¡ NO levels:retention of phlegm, heart blood stasis