| Objective:To study the characteristics of clinical manifestations, risk factors for children infected by Pseudomonas aeruginos. Take the diseases of hospital acquired pneumonia and septicemia for example.Methods:A retrospectively research was designed to study the medical records of children with hospital acquired pneumonia or septicemia both caused by Pseudomonas aeruginos in Children's Hospital, Chongqing Medical University.Results : (1)The onset of hospital acquired pneumonia due to Pseudomonas aeruginos always happened during 6 to 38 days after admission,the mean day was 15.07±9.63 days. Fever was the primary sign and it had a tendency to develop to respiratory failure and damage to other system. Congenital heart disease was the most common medical complicated(46.67%). The risk factors for children with hospital acquired pneumonia caused by Pseudomonas aeruginos involved invasive operation(100%), hospitalized in intensive care unit(86.67%),application of broad-spectrum antibiotics (80%)and surgery(66.67%). Tracheal and nasal gastric tube intubation were the most common in the factors of invasive operation, the proportion was 86.67% and 80% respectively. (2) Pseudomonas aeruginos septicemia in children often occured in infants and todders (68.75%). The common clinical manifestations of sepsis due to Pseudomonas aeruginos were fever (100%) , bloody erythra (62.5%) and the risk factors consisted of children with leukemia and surgical trauma, infants and todders. Among the sixteen children with Pseudomonas aeruginos septicemia, eleven (68.75%) of them accepted appropriate initial antimicrobial therapy and the outcome of this disease will be improved by appropriate initial antimicrobial therapy. (3)The sixteen pathogen of Pseudomonas aeruginos with more powerful of invasiveness were less resistant to Piperacillin-tapazole, Imipenem and Meropenem. This is a good news for the children's treatment of Pseudomonas aeruginos infection, but the resistance of Pseudomonas aeruginos to many antibiotics increasedy by years.Conclusion: The disease caused by Pseudomonas aeruginos in children is variable but it always progresses and aggravates. Most children with Pseudomonas aeruginos infection had complication and high risk factors, such as invasive operation, surgical trauma and immunosuppression. Appropriate initial antimicrobial therapy can improve the outcome of infection by the more invasive Pseudomonas aeruginos and in our study,Piperacillin-tapazole, Imipenem and Meropenem were more sensitive to the invasive pathogen of Pseudomonas aeruginos. |
