Magnetic Resonance Imaging Study On Electroconvulsive Therapy Of Depression

CHAPTER1 THE STUDY OF VOXEL-BASED MORPHOMETRY AND RESTING STATE FUNCTIONAL MAGNETIC RESONANCE IMAGING ON DEPRESSIONObjective:To investigate the differences in Voxel-based morphometry and resting state functional Magnetic Resonance Imaging of depressive between patients with depression and healthy controls. Methods: Ten medication-naive major depressive patients and twenty healthy control were admitted,assessed by 24-item Hamilton Depression Rating Scale(HAMD),HAMD sorces were requested≥35 in patients and≤8 in controls. The qualified ones would undergo 3.0-Tesla magnetic resonance imaging ordering to VBM and fMRI.Results: compared to healthy controls,the VBM showed major depressive patients had significantly lower grey matter density in right middle occipital gyri(P<0.001,cluster>100)without increasing grey matter,and significantly lower white matter density in left orbital frontal gyri,right caudate nucleu(sP<0.001, cluster>100)without increasing white matter。The RS-FMRI showed the ALFF of right inferior parietal lobule, left cingulate gyrus,right superior frontal gyri , left middle frontal gyri was significantly increased in major depressive patients(P<0.005);and the ALFF of right and left Posterior lobe of the cerebellum, left orbital frontal gyri, left occipital gyri was significantly decreased in MDD(P<0.005).Conclusions:The Mechanism of MDD may contract to the differences in the limbic system of brian structure and frontal gyri,cerebellum and occipital gyri of brain function. CHAPTER2 THE STUDY OF VOXEL-BASED MORPHOMETRY AND MORPHOLOGY OF RESTING STATE FUNCTIONAL MAGNETIC RESONANCE IMAGING ON DEPRESSION WITH MODIFIED ELECTROCONVULSIVE THERAPYObjective:To investigate the MDD patients'changes between before and after MECT in Voxel-based morphometry and resting state functional Magnetic Resonance Imaging,for discussing the mechanism of MECT on treating depression. Methods: The MDD were scanned in the day before MECT and the day after the eighth times of MECT by Voxel-based morphometry and resting state functional Magnetic Resonance Imaging. Results:Corrected by FEW, the VBM showed the MDD after the eighth times of MECT had significantly lower grey matter density in left middle frontal gyri(P<0.05,cluster>50)without increased grey matter,and significantly lower white matter density in left and right superior frontal gyri(P<0.05,cluster>50),increased white matter density in right superior temporal gyri, right insula. The RS-FMRI showed the ALFF of right and left posterior lobe of the cerebellum, anterior lobe of the cerebellum,right thalamus was significantly increased in MDD after the eighth times of MECT(P<0.005), right anterior lobe of the cerebellum, left inferior parietal lobule, right precentral gyrus, right Paracentral lobule was significantly decreased in MDD after the eighth times of MECT(P<0.005). Conclusions:The mechanism of ECT on treating MDD may contracted to the changes of white matter density in right temporal gyri,insula,and brain function in cerebellum.