The Influence Of Liquor On Rabbit Intraocular Pressure

ObjectTo investigate the influence of different dosages of liquor gavage on intraocular pressure in rabbits, in order to offer references for assessing the effect of liquor drinking in human on intraocular pressure.Materials and Methods48 healthy rabbits which received 56 degree liquor intragastric administration were divided into four groups by different dosages: group A, 2.5 ml/kg; group B, 5 ml/kg; group C, 7.5 ml/kg; group D received distilled water gavage as control group. Intraocular pressure was measured by Tono-Pen XL tonometer.When liquor gavage was performed on group A, B, or C, group D received corresponding dose of distilled water as control group and was named with Da, Db, and Dc respectively. Intraocular pressure of four groups was measured before the experiment as the baseline value.During the experiment, intraocular pressure was measured before( 0.0h ) and at ,0.5h, 1.0h, 1.5h, 2.0h, 2.5h, 3.0h after liquor/distilled water gavage.ResultsAll results were analyzed by SPSS 17.0 software for Windows. There were no significant differences in baseline values between groups. There were also no significant differences between intraocular pressure after distilled water gavage of different dosages and baseline values, which indicated distilled water gavage of different dosages have no influence on intraocular pressure at every detection points. The differences between group A and group Da were not significant. The intraocular pressure of group B decreased between 0-1h after liquor gavage, increased between 1-2.5h after liquor gavage, and there was significant difference between group B and group Db at 1h after liquor gavage. The intraocular pressure of group C at 1h, 1.5h, 2h was significantly lower than group Dc.ConclusionsAfter 5 ml/kg and 7.5 ml/kg liquor gavage, the intraocular pressures tend to decrease significantly in a certain period of time, and increase gradually with extension of time. More dosages of liquor, more the extent of decrease, and longer the low intraocular pressure time. 2.5 ml/kg liquor gavage has no significant influence on intraocular pressure.