| Objective: To observe the effect of combination therapy with atorvastatin and common dose of coenzyme Q10 on liver function,and determine the preventing effect to hepatic injury from statin.Methods:The patients who were diagnosed as stable angina or unstable angina in the Second Hospital of Hebei Medical University from December 2009 to August 2010 were collected. The number of patients was 83,including 55 male cases, 28 female cases. The patients were 33-81 (58.7±10.0) years old.Besides rutine treatment,all of them were treated with atorvastatin and were randomly divided into two groups: atorvastatin group (atorvastatin 20mg once per night); atorvastatin and coenzyme Q10 group (atorvastatin 20mg once per night and coenzyme Q10 20mg Bid). The liver functions of the patients were examined before taking drug, 1 week and 1 month after taking drug, Atorvastatin was suspended when hepatic enzymes of the patients rised to 3 times over normal reference limit. Exclusion criteria: the patients with serious diseases such as the basis of acute and serious infected diseases, electrolyte imbalance, serious and endocrine disorders, serious metabolic abnormalities of the kidney. The patients with obvious anomalous liver disease (aspartate aminotransferase AST, alanine aminotransferase ALT > 3 times normal reference value limit), and those allergy to statins or the patients with other definite taboo were exclused. The data were analyzed by SSPS13.0 statistical software. The measurement data were expressed with mean±standard deviation( (X|-)±SD) and the enumeration data were expressed with absoluter frequency. Statistical analysis was performed by two-sample t-test, Chi-square test, and repeated measures. P<0.05 was considered as significace.Results:The ALT levels were significantly different between the time before therapy and 1 week after treatment and 1 month after treatment in the groups. The ALT levels were not significantly different between atorvastatin group and atorvastatin and coenzyme Q10 group before therapy and 1 week after treatment, while 1 month after treatment the ALT levels between the two groups were significantly difference. The AST levels of atorvastatin group were significantly different before therapy, 1 week after treatment and 1 month after treatment, which showed a rising trend as the time of using atorvastatin increasing.While the AST levels of atorvastatin and coenzyme Q10 group in three time points was not significantly different. The AST level was not significantly different between atorvastatin group and atorvastatin and coenzyme Q10 group before therapy, while the AST levels between the two groups was remarkably different at 1 week after treatment and 1 month after treatment.Conclusion:atorvastatin auxiliary regular doses of coenzyme Q10 could prevent the statin related hepatic injury. |
