Prevention Of Contrast Induced Renal Injury In Diabetic Patients With Atorvastatin Calcium

Objective:The study included patients with type 2 diabetes, atorvastatin calcium in the coronary CTA before and after the short-term use of different doses of atorvastatin(40mg, 80mg) or saline 0.9% water treatment, and compared the renal function before and after coronary CTA,included Scr, BUN, beta 2-MG,Cysc and hs-CRP.Comparising of statins and conventional hydration therapy in the prevention of contrast induced renal injury in rats, and investigate the effects of different doses of atorvastatin on preventing contrast agent kidney injury extent. No difference in cystatin C, high sensitivity C reactive protein(hs-CRP) as the observation index further, the solution of cystatin C and high sensitivity C reactive protein in the early predictive value of contrast renal injury.Method: This study collected the hospitalized patients in the Department of Cardiology and ICU of the Department of Cardiology in the Hospital during the period from May 2014 to December 2015, and the patients were diagnosed as type 2diabetes,they need inspect with coronary CTA because of illness. 120 patients met the inclusion criteria of patients with type 2 diabetes were randomly divided into control group, atorvastatin calcium in 40 mg group and atorvastatin calcium in 80 mg group. The three groups were selected according to the condition of hypoglycemic drugs,vasodilator, diuretic therapy, on the basis of the general dose atorvastatin group checked3 days ago to check after 3 days using atorvastatin 40 mg once every night; strengthen the dose of atorvastatin calcium check 3 days ago to check after 3 days with atorvastatin80 mg once every night; conventional hydration group 12 h before the examination to check after 12 h using 0.9% Na Cl 1ml/(kg*h) continuous infusion.Results:Atorvastatin calcium treatment group had different degrees of improvement of renal function 、hs-CRP after treatment. Atorvastatin calcium(80mg) in the treatment group decreased Scr, BUN and Cysc levels than the conventional water treatment group and atorvastatin calcium(40mg) treatment group had significant difference(P <0.05),but the beta 2-MG and hs-CRP improved without obvious differences between the three groups(P > 0.05) after coronary artery CTA. Atorvastatin calcium(40mg)treatment group suggesting that the reduction of BUN had significant difference(P<0.05) to conventional water treatment group; but Scr, beta 2-MG, Cysc and hs-CRP showed no significant difference(P > 0.05) between atorvastatin calcium(40mg the treatment group) and conventional water treatment group. The incidence rate of CIN were lower of the patients in three groups, and the three groups of patients had no obvious adverse reactions in the treatment process, and the security is good.Conclusions: High dose atorvastatin calcium can effectively improve renal function after coronary CTA, may have a certain effect on the prevention of contrast induced renal injury, and no obvious adverse reactions.