The Study Of Endothelial Function And Pathological In Early-stage IgA Nephropathy Patients

Objective To evaluation endothelial function in early-stage IgA nephropathy hypertension patients by high-frequency ultrasound and to analysis the relation between endothelial function and diameter with vascular foundation, age, blood pressure, kidney pathological damage for discusses the clinical value of Flow-Mediaied Dilation(FMD).Metheods 45 cases of diagnosed early-stage IgA nephropathy patients divided into two groups, group A:26 cases of normal blood pressure; B group:19 cases of hypertension.Two groups of patients detection the base diameter and reactive hyperaemia with brachial artery by high-frequency ultrasound. To evaluation endothelial function in early-stage IgA nephropathy hypertension patients and to analysis the relation between endothelial function and diameter with vascular foundation, age, blood pressure, kidney pathological damage.Results l.The vascular endothelium-dependence dilation(FMD%) (4.86±1.97) % was lower in group B than that in group A (9.40±1.33)%(P< 0.05), The glomerular damage score (4.42±1.72) was higher in group B than that in group A (3.67±2.11) (P<0.05). The renal tubular injury score (3.56±1.62) was higher in group B than that in group A (2.97±1.61) (P< 0.01). The difference had statistics significance.2. The hemodialysis patients's FMD% had a high correlation with systolic blood pressure (SBP (r=-0.310)), the glomerular damage score (r=-0.332) and the renal tubular injury score (r=-0.596) (P<0.05);. FMD had no correlated with age (r=-0.283) and diastolic blood pressure (DBP) (r=-0.121) (P>0.05).3.The SBP and FMD% was different between fore groups which glomerular had different immune complex deposition.GroupⅡ's SBP (138.73±13.78) mmHg was higher than the groupⅠ's (127.86±11.64) mmHg, GroupⅡ's FMD%(5.16±1.23)% was lower than the groupⅠ's (6.59±1.35)%. The difference had statistics significance (P<0.05).The fore groups had no differente between DBP (127.86±11.64mmHg VS 132.16±12.39mmHg VS 134.59±11.83mmHg)(P>0.05).The SBP was not differente in groupⅠ, groupⅢand group IV(6.59±1.35% VS 6.32±1.58% VS 5.98±1.62%) (P>0.05)Conclusions:Early IgA nephropathy hypertension patients was existed lower endothelial function and higher glomerulus and kidney tubule damage befor decline in renal function. The decline of Endothelial function can promote kidney pathological damage. The patients has sedimentary IgG in glomerulus with higher systolic blood pressures and endothelial function. High-frequency ultrasound can be used to test the endothelial function in early IgA nephropathy hypertension patients...