Clinical Research Of Anticancer Effect Of Plant Extracts Dammarane Sapogenin On Tumor Treated With Adjuvant Chemotherapy

ObjectiveThis randomized controlled clinical trial intends to discuss the clinical research of anticancer effect of dammarane sapogenin on tumor treated with adjuvant chemotherapy.Based on after cancer chemotherapy the reaction and toxicity of the prospective controlled clinical research, observation of Dammarane Sapogen adjuvant therapy of cancer chemotherapy for clinical research and the influence on the quality of life of the patients, and for Chinese medicine control to provide the scientific basis for tumor.MethodsResearch objects are patients who were diagnosed as tumor from April 2009 to December 2010 and it's safe in clinical application.From Vancouver hospital cancer center chemotherapy patients through strict screening, and two indications or above level, professional doctors recognized by a qualified after trying cases.60 cases qualified biooxyrate cases, all manasseh in chemotherapy and application of silane glucoside tuple auxiliary treatment, use simple randomized method,â… group established in chemotherapy for the treatment group, based on alkoxy adjuvant treatment (Dammarane Sapogen, were 30 cases,â…¡group only received chemotherapy as control group,30 cases,; 1 time/day 200mg/day. For about 8 weeks 1 treatment treatment. Observation period:first day, by chemotherapy treatments for 8 weeks before and after the therapy began a therapeutic effect evaluation 1 times respectively, and follow-up time for 10 weeks. Observing indexes including physically Karnofasky physically scores, the quality of life score. ResultsThe treatment group for 36.7%, part catabatic rate for 50.0% active; The control group for 13.3%, part catabatic rate for active 50.0%, progress rate of 36.7%. Two groups of comparisons by rank and inspection, no significant differences. But think of silane glucoside tuple manasseh adjuvant treatment can improve patients'illness chemotherapy. Considering the lack of concurrent to ratings, the influence of factors, using Logistic curative effect, and the results indicated that regression analysis methods between groups significant differences in treatment group and control the relative to the relative risk (RR) for 5.47, says the risk is group cases progress in treatment group 5.47 times. Two groups of patients quality of life score before chemotherapy compared by t test, no significant difference, comparable. Two groups of patients after chemotherapy, quality of life score by t-test comparison was significant difference (P<0.05), two groups of quality of life score before decreased significantly, but the quality of life score in treatment group than controls, can think drop of silane glucoside tuple manasseh adjuvant treatment cancer chemotherapy can control patients because of chemotherapy lead to quality of life decline. Two groups were compared before physically score chemotherapy by t test, no significant difference, comparable. Two groups of patients after chemotherapy physically score by t-test comparison was significant difference (P<0.05), the treatment group after chemotherapy physically score more chemotherapy before they get increases, can think of silane glucoside tuple manasseh adjuvant treatment with chemotherapy after chemotherapy can improve the physical condition.ConclusionEffect of Adjuvant treatment cancer chemotherapy of dammarane sapogenin group can greatly improve the quality and improve survival in patients with clinical symptoms. Dammarane sapogenin of adjuvant treatment for patients with tumor group has good clinical curative effect, have certain synergy. Anyhow, of dammarane sapogenin adjuvant treatment caused by chemotherapy can reduce the adverse reaction of chemotherapy, improve the quality of life of the patients.