The Impact Of Fang-Acupuncture Of Parkinson's Patients On FMRI And Preliminary Study Of Its Efficacy

ObjectiveParkinson's Disease(PD), also named as parelysis agitans, is a kind of neurodegenerative disease, which usually occurs in middle-aged or senile patients. At present, there is no medicine or surgical which is effective enough to stop the development of this disease.A large number of clinical research and experimental studies had shown that acupuncture can improve symptoms of tremor and control the progression of this disease. But the objective evidence is not sufficient. Functional magnetic resonance imaging as an observation which non-invasive and convenient, has the advantage in the diagnosis of PD and the observation of the curative effect. Therefore, by observing the impact of Fang-acupuncture of Parkinson' s patients, we elementary discuss the immediate result and mechanism of acupuncture to PD.MethodsChosing 10 cases of Parkinson's disease. Evaluate their UPDRS score, motion experiment and fMRI before and after treatment. Recording its scale and brain functional magnetic resonance data, using paired T test to analysis the impact of treatment on FMRI and its immediate effect. Use T test to analysis the difference between two groups.ResultsTiming motion test of both hands of post-treatment have increased than that of prior-treatment. The difference had no statistical difference(p>0.05).Timing motion test of turning round,standing up and 10 metres walking of post-treatment haven't decreased than that of prior-treatment.UPDRS scores of part III of post-treatment has decreased than that of prior-treatment. The difference had no statistical difference(p>0.05).Increased ReHo were found in both Parahippocampa Gyrus,Amygdala_L,Insula_L,both Superior Temporal Gyrus,Temporal_Mid_L,both Putamens,Caudate_L,both Lateral Globus Pallidus,Corpus Callosum etc. (p<0.05).ConclusionThe Fang-acupuncture can improve movement in PD'patients immediately to some extend. But the difference had no statistical difference(p>0.05).The Fang-acupuncture may improve movement and sentiment by activating the related brain function.