| ObjectivesParkinson's Disease(PD) is a kind of neurodegenerative disease, which usually occurs in middle-aged or senile patients. Recently it tends to be younger, and need cure for lifetime. At present, Western medicine mainly uses drugs and surgical methods, but there is no medicine or surgical which is effective enough to stop the development of this disease. A large number of clinical research and experimental studies had confirmed that acupuncture, a method of traditional Chinese medical science, can improve symptoms and control the progression of this disease. But there is no sufficient objective evidence.Functional magnetic resonance imaging as an observation which is non-invasive and convenient, has the advantage in the diagnosis of PD and the observation of the curative effect. Therefore, using fMRI to observe the brain functional efficacy of scalp acupuncture on Parkinson's patients, and the change of central nervous system, we elementary discuss the mechanism of acupuncture to PD.MethodsEleven Parkinson's patients participated in the experiment. The study was divided into two groups:before and after acupuncture treatment, and took eleven healthy volunteers matched the group before treatment; the other group chose Chorea-Trembling Controlled Area, retaining the needle for 30min, and take the fMRI scan about 25min after withdrawal needle. The date was analysised by SPM software, and the newly published regional homogeneity (ReHo) approach was applied for fMRI data analysis to observe the differences between the two groups separately。Therapeutic evaluations of PD are UPDRS measuring scale,H-Y grade,Parkinson's patients subjective symptom grade, and took the sacle before and after theatment, then analyse statistical difference.ResultsCompared with the normal control subjects, the patients with PD showed significant ReHo increases in the bilateral Paracentral Lobule, right SMA, bilateral medial superior frontal gyrus, right superior frontal gyrus, and bilateral anterior cingulate gyrus; and decreases in the left cerebellum posterior lobe, left postcentral gyrus, and precentral gyrus. Compared with the patients with PD before acupuncture, the patient after acupuncture showed significant ReHo increases in the left middle frontal gyrus, right inferior parietal lobule, left cerebellum anterior lobe, and cerebellum posterior lobe. The UPDRS PartⅢ, movement score, had no significant difference(P> 0.05) before and after the acupuncture treatment. After 30min of the treatment, there was no significant changes in patients'subjective symptoms. The day after the acupuncture treatment, there was improvement in their tremor, fatigue, pain, sleep, anxiety and so on.Conclusion1.Compared with the normal control subjects, the patients with PD have difference in regional homogeneity, and it says that brain functional activity of the patients with PD was damaged in some brain regions, so lead to various kinds of clinical symptoms.2. Scalp acupuncturing could lead to the chang of brain functional activity, which is mainly shown in the frontal gyrus,inferior lobule and cerebellum lobe of difference of regional homogeneity. Further, it means the frontal gyrus,inferior lobule and cerebellum lobe have important compensatory role in the brain functional efficacy, and have some significance in improving PD symptoms.3. After scalp acupuncturing, the UPDRS movement part, had no significant difference within a short period of the patients with Parkinson's disease; but the day after treatment, part of the patients'subjective symptoms have some improvement. And this means that the treatment of scalp acupuncture on PD has some curative effect.
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