Ultrasonic Evaluation Of Intervention Tongguan Capsule Atherosclerosis Vascular Endothelial Dysfunction In Clinical And Experimental Study Of Clinical And Experimental Research

ObjectivesExperimental study of Tongguan Capsule atherosclerosis intervention of vascular endothelial function of the impact of the damage, the use of non-invasive ultrasound detection of brachial artery flow-mediated vasodilator function (flow mediated of brachial artery, FMD) and nitroglycerin-mediated vasorelaxation response (non-flow mediated of brachial artery, NMD), and clinical research, observation Tongguan Capsule on patients with stable angina pectoris of vascular endothelial function, the use of ultrasound evaluation of endothelial function, through the crown of capsules on vascular endothelial function and its mechanism.MethodsExperimental study selected 36 healthy male New Zealand white rabbits were randomly divided into blank control group, high fat control group, the atorvastatin group, Tongguan Capsule large, medium and small dose group, n =6, blank the control group was fed the basic diet group was more than immunity endothelial injury induced by high fat diet combined AS rabbit models fed high-fat diet high fat control group (3% cholesterol,4% lard,8% and 85% yolk powder diet), atorvastatin group on the basis of the high fat group fed daily atorvastatin 5mg/(kg·d); Tongguan Capsule small, medium and high dose group on the basis of the daily fat group Capsules were fed through the crown 3mg Clinical study selected in March 2009~October 2009 in the Guangdong Provincial Hospital of cardiac centers were 87 cases of stable angina patients were randomly divided into Tongguan Capsule+atorvastatin group (n=28), pass the crown capsule group (n=29), atorvastatin group (n=30), the treatment period of 3 months before and after treatment using ultrasound to detect vascular endothelial function in FMD, NMD and lipid determination.ResultExperimental results:6 weeks, the highest capsule dose group communication, atorvastatin group and the high fat control group FMD, NMD statistically significant difference (P<0.05); Tongguan capsule high dose group NMD higher than the atorvastatin group, but no significant difference between the two groups no significant difference in FMD; Tongguan Capsule large, medium and low-dose group could improve endothelial function, but pass the highest dose group than in the capsule, a small dose group is more evident. Clinical Results:After treatment, compared with Tongguan Capsule, Tongguan Capsule+atorvastatin group FMD was significantly higher (P<0.05), while Tongguan Capsule group and atorvastatin group, the difference was not significant.ConclusionTongguan capsule can significantly improve the atherosclerotic vascular endothelial function, which has a failing Laie Tuo independent atorvastatin improve endothelial function in the role, but also in improving the NMD, the pass may be superior to atorvastatin capsule crown statins。Tongguan Capsule can improve in patients with stable angina pectoris vascular endothelial function, the United atorvastatin improve endothelial function in lipid-lowering effect than simple application of Tongguan capsule.