Valuation About Curative Effect Of Treating Parkinson's Disease With Wumei Wan

ObjectiveAlthough the course of Parkinson's disease (PD) is long and the treatment is difficult, it provides a very long treatment time for us at the same time. Therefore, we should make use of this good opportunity and develop the TCM treatment of PD, which is one of the direction that we work hard. This research observes the Wumei Wan's clinical curative effect and security, trying to look for a new way to the PD.MethodThis study elects the PD patients as studied objects to take a prospective random parallelism comparison survey. These patients were grouped randomly into two groups:Thirty-three in either group. We gave the Treatment Group (TG) Decoction of PD No.1 or PD No.2 and madopar one dose per day. And the Comparison Group (CG) takes the madopar referring to the randomization, the dose was as same as Treatment Group. The test ran referring to the test requirement rigorously. At last, All cases of EG and CG has not been lost. Observing cycle of the two groups were both three months. SPSS 17.0 software was used to handle datum. T-test was used to handle quantitative datum and rank sum test was used to handle categorical datum.ResultPrior treatment, gender age, course of disease, H-Y grading of pathogenic condition and UPDRS score, motion experiment,Bristol stool scale score,PDSS score and medication of the two groups had no statistical difference(p>0.05). the basal line of two groups is coincident, and with comparability.The outcome shows:Contrast the integral of motion experiment of two groups of prior-treatment to which of post-treatment, the TG's timing motion test of right hand of post-treatment has increased than that of prior-treatment. The difference is significant (P<0.05).Contrast the integral of UPDRS of two groups of prior-treatment to which of post-treatment, the TG's integral of post-treatment of ordinary activity,movement function has decreased than that of prior-treatment. The difference is significant (P<0.05). The CG's integral of post-treatment of UPDRS scale is not improved significantly (P>0.05).Contrast improvement ratio of the integral of UPDRS of two groups of post-treatment, in terms of the improvement ratio of the integral of ordinary activity, the EG is superior to the CG. The difference is significant (P<0.05). But in terms of the other part of UPDRS, the difference of the two groups is not significant (P>0.05)。Contrast the integral of Bristol stool scale of two groups of prior-treatment to which of post-treatment, the TG's score of post-treatment has increased than that of prior-treatment. The difference is significant (P<0.05).And the improvement ratio of the integral of Bristol stool scale of two groups of post-treatment, the TG is superior to the CG.Contrast the integral of Parkinson sleep scale of two groups of prior-treatment to which of post-treatment, the TG's score of post-treatment has increased than that of prior-treatment. The difference is significant (P<0.05). And the improvement ratio of the integral of Parkinson sleep scale of two groups of post-treatment, the TG is superior to the CG.Before and after treatment,40 patients of both groups, which have undergo the routine blood, urine, electrocardiogram, liver and kidney function tests, were not found the abnormal changes related to treatment.ConclusionThrough the clinical prospective random parallelism comparison trail, we can see there is a better curative effect of PD No.1 or 2 for patients with PD. When the trail was over, the availability percentage of TG is 85%, while that of CG is为54.5%. And the constipation and sleep disorder of TG has improved. These indicate that the curative effect of treatment of EG is superior to that of CG.