Explore Chaishao Liujun Tang Reduced Intervention Chronic Hepatitis Binter Leukin-10, Interleukin-18 Level Changes

backgroundChaishao liujun tang is guangdong hospital of traditional Chinese medicine, liver specialized subject agreement square, Always have already undertaken, choice of optimization effect assessment, And find wood in improving Chaishao liujun tang clinical symptoms and signs, inhibiting liver inflammatory activities, promote HBeAg serum conversion, improve liver fibrosis, promote HBV DNA, shade and delay the HBV YMDD variation are obviously curative effect, And in the process of taking no adverse reaction, To prolong patient life, improve survival quality has important significance, But currently lack of wood mechanism Chaishao liujun tang.ObjectivesThis clinical research aimed to preliminary before through clinical itself controlled study, Observe spleen deficiency stomach type chronic hepatitis b patients' bodies IL-10, IL-18 level changes, Explore Chaishao liujun tang reduced intervention chronic hepatitis b patients'immune mechanism, After further for controlled clinical trial and thorough discussion, provides the basis.MethodsAll the patients in May 2010 all comes to 2011 February guangdong hospital of traditional Chinese medicine on hepatitis b patients out-patient clinic service, In strict accordance with the inclusion criteria included cases 34 patients, Taking firewood Chaishao liujun tang (drug composition:Chaishao, Baishao, Dangshen, Baizhu, Fuling, Chenpi, Fabanxia and Gancao, licorice dialectical deductions), Day 1 agent, Meanwhile coupled lamivudine tablets, Each 100mg qd, Treatment for six months. In the treatment of 3 and 6 months after the laboratory (IL-10, IL-18, liver function, second liver two half-and-half, HBV DNA, liver fiber four, HBV YMDD) motif with observations, The establishment of database, All data entry database, SPSS17.0 statistical software packages used statistical data analysis, Counting material use X2 inspection, Measuring material use t-test.Result1. In IL-10 and IL-18, after treatment, IL-18 levels rise, own comparison between before and after significantly (P<0.05). IL-10 level declined, but their comparison between before and after no significant differences (P>0.05).2. In improve liver inflammatory activities, lier inflammation after treatment, get a different degree of recovery will ALT, AST change situation analysis, all have significant difference (P<0.05).3. In HBeAg serum conversion, treatment 3 and 6 months after efficient respectively 0 and 14.3%; At the same time, IL-18 increased levels of HBeAg quantitative decline.4. In HBV DNA Yin turn, treatment 3 and 6 months respectively after efficient 9.3% and 64.7%and;At the same time, IL-18, HBV DNA increased levels of quantitative decline.5. In the improvement of liver fibrosis, in treatment process to the PCâ…¢,â…£LN, C- statistical analysis respectively, HA, itself a significant difference between before and after controls (P<0.05).6. No one appeared YMDD variation.ConclusionAfter half a year before clinical itself controlled study, Confirm Chaishao liujun tang joint lamivudine treatment for chronic hepatitis b type of pixu stomach patients had good curative effect, In improve liver inflammation, promote HBeAg serum conversion, accelerate HBV DNA Yin turn, improve liver fibrosis, etc. Remarkably, After the preliminary discussion also found, This treatment can improve IL-18 level, and IL-10 level without significant decline, Help clear intracellular virus, also not abate anti-inflammatory factor role, So Chaishao liujun tang great may by mobilizing immune factors level, Improve immune status to improve antiviral treatment. Meanwhile, the study also controlled study, for the next Chaishao liujun tang discussed wood mechanism of the tang provides a preliminary direction.