The Ears Pressure Bean Treatment Platinum-based Regime Chemotherapy Induced Nausea And Vomiting Clinical Research

BackgroundChemical medication (Chemotherapy) is currently the main treatment cancer patients with one. In malignant tumor in the chemotherapy, nausea, vomiting is the most common adverse reactions, especially cisplatin, its cause ou rate almost close to 100%. Severe vomiting can lead to dehydration, electrolyte imbalance, weight loss, gastrointestinal mucosal hemorrhage, even shock etc, make a patient treatment adherence dulness therapy, even lower, suspend effective treatments. Some patients because of pain bear hard and refuse treatment, the serious influence patients nutritive condition, the quality of life, and therapeutic effect. Therefore, to discuss nausea, vomiting response prevention and treatment, to guarantee the normal chemotherapy plans and successfully completed, improve the quality of life of the patients and prolong its life period, etc have important practical significance.PurposeThis study through the observation of the ears pressure bean treatment platinum-based regime chemotherapy induced nausea and vomiting for the clinical curative effect of the clinical treatment, provides the basis. Through the research of the ears pressure bean treatment platinum-based regime chemotherapy induced nausea and vomiting, and explore the efficacy and safety of its feasibility and clinical significance. MethodsThis research collected guangzhou university of traditional Chinese medicine first affiliated hospital oncology October 2010 in March 2011 containing cisplatin, or nida platinum, or carboplatin scheme of 50 patients with chemotherapy. By contrast between groups of clinical research methods, selected cases of the group, divided into the treatment group and control group, and the control group with stop spitting medicine, simple in treatment group based on the spit medicine combined with the ears pressure beans, observation time 1 days start from treatment lasted until the first six days after, observe evaluate patients before and after the treatment, through the observation of nausea and vomiting appetite symptoms, KPS score, clinical syndrome integral, adverse reactions, comprehensive evaluation of the ears pressure bean treatment chemotherapy sex nausea and vomiting both safety and efficacy.ResultsThis study chemotherapy treatment correlation nausea and vomiting, this paper discusses the method of the ears pressure beans for the platinum drugs cause nausea and vomiting correlation of chemotherapy curative effect, the results are as follows1. Control nausea effect:after the first days from treatment to the first six days of the nausea grading perspective, treatment group and control group in the first days of the curative effect of control nausea without obvious advantages. From the first 2 to 6 days to see, (P<0.05), and the difference between the two groups was statistically significant, the treatment group than in control group.2. Stop ou curative effect aspects:in the acute vomiting, two groups of comparisons not statistically significant (P>0.05). In late in the sexual vomiting, chi-square test, (P<0.05, P<0.01), the difference between the two groups was statistically significant。3. Appetite improvement:the first days and the first six days, two groups of comparisons no significant difference (P>0.05), indicating that the first days and the first six days treatment group compared with controls appetite improve not obvious. Article 2,3,4,5 days P<0.05, two groups of comparisons with a statistical significance. The ears pressure beans that can effectively improve patients chemotherapy treatment after the anorexia, appear in the treatment of 2,3,4,5 days obviously.4. Clinical syndrome integral improvement:treatment group abdominal distension, gas, hiccups symptoms after treatment significantly improved than before treatment (P<0.05), and the control group before and after treatment were no statistically significant difference (P>0.05). Explain clinical syndrome integral treatment group was better than control and improvement of the ears pressure bean intervention is effective;5. Quality of life:treatment group KPS score before and after therapy to improve situation was obviously better than control group (P>0.01), That could significantly improve the ears pressure beans physical state; patients6. Adverse reactions:this study appear chemotherapy reaction dizziness, headache, abdominal discomfort and constipation. The treatment group obviously lower than in control group (P<0.05), this research of the ears pressure beans can reduce in chemotherapy induced associated symptoms.ConclusionThe clinical research proof:①the ears pressure beans can control nausea happen degree and the late sex vomiting.②the ears pressure beans can effectively relieve abdominal distension, gas, such as improved clinical symptoms, with hiccups physical state, improve patient survival quality.③of the ears pressure bean safety, no obvious side effects.