Initial Research In Cerebral Microbleeds Of Patients With Adult Moyamoya Disease

Partâ… Incidence and Affecting Factors of Cerebral Microbleeds in Adult Patients with Moyamoya DiseaseObjective:To investigate the incidence and affecting factors of cerebral microbleeds (CMBs) in adults with moyamoya disease (MMD).Method:A total of 32 adult patients with MMD confirmed by digital subtraction angiography were selected consecutively from department of neurology in Jinling hospital from November 2009 to June 2010. All patients were performed with high intensity magnetic resonance imaging (3.0T) including routing sequences and susceptibility weighted imaging. The clinical data of these patients, including levels of systolic blood pressure, diastolic blood pressure, mean arterial pressure, level of fasting blood glucose, plasma fibrinogen, and degree of leukoaraiosis were collected. The relationship between the characteristics of CMBs and these clinical parameters was analyzed.Result:There were 15 microbleeds foci of 13 hemispheres in 11 patients with MMD. The incidence of the microbleeds was 34.4%.There was no statistical difference between patients with and without CMBs in age, gender, hemorrhage symptoms, systolic blood pressure, diastolic blood pressure, mean arterial pressure, leukoaraiosisand, and plasma fibrinogen. However, the level of fasting blood glucose was significantly different between the two groups (p=0.034)..Additionally, logistic regression showed that the level of fasting blood glucose was the independent risk factors of the microbleeds in adult MMD (p=0.029; OR=10.90; 95%CI:1.28-92.61).Conclusion:Our results indicated that adult patients with MMD showed a high incidence of CMBs, and high fasting blood glucose was a crucial factor contributed to CMBs.Partâ…¡The Relationship of Cerebral Microbleeds Patterns and Anterior Choroidal Artery-posterior Communicating Arteries in Adult patients with Moyamoya DiseaseObjective:To investigate the relationship between distribution patterns of microbleeds and the morphology characters of anterior choroidal-posterior communicating artery (AChA-PComA)in adult moyamoya patients.Method:A total of 32 moyamoya patients confirmed by digital subtraction angiography were selected consecutively from department of neurology in Jinling hospital from November 2009 to June 2010. All patients were performed with high intensity magnetic resonance imaging susceptibility-weighted imaging. These patients were divided into 3 groups based on angiographic findings of AChA-PComA:Group 1 was referred to normal or mild to moderate dilation of AChA-PComA, Group 2 to exceeding dilation and abnormal extension of AChA-PComA, and Group 3 to disappearance of AChA-PComA. The relationship of distribution patterns of microbleed focis and the vascular characters were analyzed.Result:Eighty percentage of microbleeds focis was observed in deep brain territory especially in deep periventricular white matter (67.7%). The incidence of the microbleed foci was not statistical different among the 3 groups (p=0.16), but patients were more likely to represent deep periventricular white matter microbleeds foci in group 2(p=0.03).Conclusion:The distribution of microbleeds foci in adult patients with moyamoya disease was of certain characteristic. The exceeded dilated and extended AChA-PComA was found to be related to the microbleeds in deep and periventricular white matter.