| Background and purpose:Coronary heart disease is one of the diseases of the major threat to human health today.Its prevalence and mortality rates continue to rise, economic burden of it causes,has been ranked the forefront of various diseases, At present, China has more than 10 million patients with coronary heart disease,it has became a threat to people's lives and "the first killer " to health.Coronary atherosclerosis is the result of many factors.In this study, starting from multi-vessel disease, analyzing the correlation between the risk factors of coronary heart disease and coronary artery multi-vessel disease used univariate and multivariate for clinical, prevention of coronary multi-vessel disease occurs, and greatly reduce health care consumption.Method:Select 20010.1-2010.7 in China-Japan Union Hospital of Jilin University, Department of Cardiology 107 cases of using coronary angiography.According to results, they were divided into two groups: single-vessel disease group and multivessel disease group. Exclusion criteria: (1) Blood, liver and gallbladder, rheumatism, immune system diseases (2) Various coagulation disorders (3) Peripheral vascular disease (4) Acute and chronic infection (5) Surgery Trauma Cancer (6) Poor compliance,the inspector can not tie in with.Coronary angiography in the China-Japanese union Hospital in Jilin University, Department of Cardiology, physician via the radial artery or femoral artery approach, performed around coronary angiography, Lines, respectively, left and right coronary angiography.contrast medium for the Ultravist(370)。Coronary artery stenosis≥50% as a meaningful.Selected six vessels:left anterior descending artery, left circumflex artery, first diagonal branch, posterior branch of left ventricle, acute marginal artery and descending posterior branch.The multi-position projection, coronary artery with no stenosis regarded as the normal. The six vessels with a stenosis as a single vessel disease, two or two above and left main disease or right coronary artery stenosis were defined as multi-vessel disease.Asked in detail about whether the admission history of hypertension, diabetes, smoking history. the next day entering hospital TC,TG,HDL-C,LDL-C should be taken on an empty stomach.TC>5.2mmol/L or TG≥1.70mmol/L or HDL≤1.04mmol/L or LDL≥3.12mmol/L as dyslipidemia, Fibrinogen> 4g/L is the Dyslipidemia. Has been taking antihypertensive drugs, hypoglycemic agents and lipid-lowering drugs by repeated drug, Clear hypertension and (or) a history of diabetes, is currently on medication, and the patients of blood pressure and blood sugar has been control, still was diagnosed with hypertension and (or) diabetes. Statistical software used for data processing SPSS13.0. Smoking, hypertension, diabetes, family history of coronary heart disease indicated by binary variables (yes=1,no=0), Age, sex, categorical variables are expressed using binary variables (male=0, female=1,age<60 years=0,age≥60 years=1) they were divided into 2 groups by coronary artery stenosis:normal group, Coronary heart disease group CHD group was divided into two subgroups of single-vessel disease group, multivessel disease group. Measurement data showed a normal distribution with mean±standard deviation, skewed distribution of the measurement data using the median. Normal distribution of measurement data between the two groups using unpaired t test, The relationship between the measurement data using linear correlation analysis; Skewed distribution of the measurement data between the two groups using Wilcoxon rank sum test, the relationship between the measurement data analysis using Spearman rank correlation; Rate, proportion compared by x2 test; P<0.05 was considered statistically significant difference.Results:1. Diabetes, Hypertension, Elevated low-density lipoprotein, Lower high-density lipoprotein had significant differences in the prevalence of single-vessel disease with multi-vessel disease(P<0.05). A multi-vessel disease as the dependent variableandGender, age≥60 years of age, family history, diabetes, FIB abnormalities, smoking, high TG, high LDL, low HDL as independent variables for multivariate analysis, Diabetes, hypertension, elevated low-density lipoprotein, high density lipoprotein lowering and multi-vessel disease incidence differences (P<0.05), is a multi-vessel disease risk factors.2.The patients of aged≥60 years, smoking, elevated fibrinogen with a higher proportion of multi-vessel disease.Conclusion:1. Hypertension, Diabetes, Elevated low-density lipoprotein, Lower high-density lipoprotein were risk factors for multi-vessel disease.2. The patients of aged≥60 years, Family history of coronary heart disease,smoking, elevated fibrinogen were independent risk factors of multi-vessel disease...
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