The Clinical Application Of The Indices Of The Comprehensive Test Of Hyperlipidemia To Cardiovascular Diseases

Background and purpose:cadiovascular diseases are a threat to human health. Atherosclerosis is the major cause leading to myocardial infarction and cerebral infarction in some countries and regions, heart diseases caused by coronary atherosclerotic heart disease. The more serious the index of thrombosis, the larger the proportion of hyperlipoidemia. Blood viscosity is in the right proportion to thrombosis while blood viscosity. Is closely related to the increase of serum cholesterol and Triglyceride.This paper mainly studies the clinical application of the indices of the comprehensive test of hyperlipidemia to cardiovascular diseases.Method:The object of study fall into 2 parts. The first part,as a group of patients with coronary disease, includes 200 patients with coronary disease diagnosed by and admitted to the department of cardinal internal medicine,No One Affiliated Hospital of Jiamusi university, from February to November,2010, of whom 120 were male and 80 were female, whose age ranged from 38-72 and whose average age was59.00±8.01 years of age. The second part,as a group of patients with cerebral infarction, includes 120 patients with cerebral infarction diagnosed by the department of internal neurology,No one Affiliated Hospital of Jiamusi University, from March to November,2010,of whom 74 were male and 46 were female, whose age ranged from 42-77 and whose average aged 60.5±9.1 years old. The normal group includes 220 hospital staff (July-August,2010),of whom 120 were male and 100were female, and average age 53.4±6.5 years of age, and the possibility of diabetes, kidney disease and hepatitis. The general introduction to the group of patients with coronary disease and the group of patients with cerebral infarction,including their age,body weight,blood pressure,blood sugar which are slightly higher than those of the normal group without any statistical difference(P>0.05) or age group difference or difference of sex.A retrospective analysis of the patients with cardiovascular diseases was conducted and a normal group was set up,whose blood lipids were compared and detailed information collected,including admission number, time for admission,name, sex age etc and the medical history of the patients:smoking drinking hypertension,diabetes etc and the. metabolic markers of the patients including blood sugar, insulin, TC,TG, HDL-C, LDL-C, VLDL-C, ApoA1, ApoB, Lp(a)。The indices of the test of hyperlipidemia were conducted by the bio-chemo lab of the Department of testing, No one affiliated hospital of Jiamusi university. The Appratus No was OLYMPUS 5421, TC determines by CHOD-PAP and Olympus reagent;TG determines by GPO-PAP and Olympus reagent; HDL-C determines by RT-PCR and Beijing golden seal reagents; Determined by LDL-C:recommended for formula calculation or RT-PCR(1).This study adopts the formula to calculate. And determine ApoA1 by ITM and Beijing Golden Seal Reagent ApoB by ITM and Beijing Golden Seal Reagent and Lp(a) by Enzymaticcyclingassay and Shanghai kehua Seal Reagent calibrators were used respectively to go with corresponding equipment and their evaluation can be traced to the reference methods and all the data statistics are dealt with by SPSS11.5 softwares. P< 0.01 for differences have statistics, p<0.05 for differences have statistics, the measurement of data by x±s said. two groups are few more uses two separate samples. texamineThe results:(1) The group of patients with coronary disease is compared With the normal group, the value of its serum,TC, TG ApoB, the density of LDL-C, ApoB,LDL-C ApoA1, LDL-C/HDL-C, Lp(a) is obviously higher than that of the control group (P<0.01), the density of ApoA1,HDL-C is relatively lower than the control group (P<0.01); (2) The group of patients with cerebral infarction was compared with the normal group:the value of its serum,TC,TG, ApoB,the density of LDL-C,ApoB/ApoA1 LDL-C/HDL-C is apparently higher than the control group (P<0.01), ApoAI,the density of HDL-C is significantly lower than the control group (P<0.01); (3) coronary disease group and control group (physical examination group) blood fats each target rate of abnormality (%):Namely TC, TG, ApoB, LDL-C, the Lp(a) result surpasses the ratio which the reference value upper limit occupies (%), as well as ApoA1, the HDL-C result is lower than the ratio which the reference value lower limit occupies (%). Carries on during two groups to compare to analyzes, demonstrated that the partial target difference has statistics significance (P<0. O1,P<0.05). (4) cerebral infarction group and control group (physical examination group) blood fats each target rate of abnormality (%):Namely TC, TG, ApoB, LDL-C, the Lp(a) result surpasses the ratio which the reference value upper limit occupies (%), as well as ApoA1, the HDL-C result is lower than the ratio which the reference value lower limit occupies (%). Carries on during two groups to compare to analyzes, demonstrated that the partial target difference has statistics significance ((P<0.01,P<0.05). (5) coronary disease group divides into four groups, in four groups of cases blood fats each target rate of abnormality (%) comparison:The cardiac arrest and the anemic myocardiopathy's rate of abnormality generally and the angina pectoris rate of abnormality must be higher than the symptomless, namely coronary disease condition is more serious, each target's rate of abnormality is also higher, assumes certain relevance with the condition, is consistent with the research report. Partial target each group of differences have statistics significance. (6) in coronary disease group, the cerebral infarction group and the control group TC and TG are normal, other 5 target's rate of abnormality (%) analyzes, coronary disease group and the cerebral infarction group's rate of abnormality (%) is higher than the control group, has statistics significance (P<0.01)Conculusions:1. Coronary disease group and cerebral infarction group T C, T G, ApoB and, LDL-C and the Lp(a) mean value is higher than the control group, but HDL- C and the ApoAl mean value is lower than the control group, has statistics significance. The prompt besides TC, TG, other each item of blood fats target's union examination may have the development useful biochemistry target as the early prediction heart cerebrovascular disease.2. Coronary disease group and the cerebral infarction group and the control group compare:Namely TC, TG, ApoB, LDL-C, the Lp(a) content surpasses the ratio which the reference value upper limit occupies (%), as well as ApoAl, the HDL-C content is lower than the ratio which the reference value lower limit occupies (%), the difference has the significance (P<0.01)。3. Different type coronary disease blood fats each target rate of abnormality (%) comparison:The cardiac arrest group and the anemic myocardiopathy group are higher than the symptomless group and the angina pectoris group, namely coronary disease condition is more serious, each target's rate of abnormality is also higher, assumes certain relevance with the condition. Partial target each group of differences have statistics significance.4. To coronary disease group and cerebral infarction group statistical analysis:The result showed that TC and TG two items even normal, other 5 target's rate of abnormality (%) is higher than the control group, has statistics significance (P<0.01), is in coronary disease group, the cerebral infarction group and the control group TC and TG is normal, other targets still had a part of unusuality. Prompts examines TC and the TG target purely, is insufficient to understand that in vivo lipid metabolism level, should examine many targets jointly, intervenes the positive function to the heart cerebrovascular disease early diagnosis and the early time.