Studies On Pharmacodynamics And Anti-inflammatory Mechanism Of Fuyankang Suppository

Objective:In this paper, Taking the compound preparation of treditiongal Chindese medicine Fuyankang suppository as a study target, mainly to study the in vitro antibacterial, anti-inflammatory, analgesic effect and the mechanism of anti-inflammatory effects, to determine the effect of Fuyankang suppository with the treatment of vaginitis cervicitis, to provide a reliable pharmacological proof for vaginitis of efficacy for Fuyankang suppository clinical applications and a basis proof for their effect to play.Method:In this paper, ratting vaginal,cervicitis model by Phenol glue,the use of anti-bacterial experiments; trichomonas vaginalis in vitro killing experiments.xylene-induced ear edema test; the test of capillary permeability in mice;agar induced granuloma test; hot plate analgesia test; glacial acetic acid induced writhing pain experiments to study the treatment of vaginitis fuyankang, the pharmacological effects of cervictis; and replicating by measuring the phenol glue rat vagina, cervicitis model animal vagina and cervix tissue PGE2 content; phenol paste copy mice vaginitis, cevictis VitC experimental animals adrenaline content of the indicators used to study Fuyankang suppository pharmacody of anti-inflammatory role played by the mechanism.Results:Through these pharmacodynamic experiments showed fuyankang effervescent suppository copy of phenol glue rat vaginitis, cervicitis has obvious therapeutic effect on the performance of the rat vagina, cervix pathological mucosal inflammation 11 test indicators (the number of inflammatory cells, the total area of inflammatory cells, etc.) have different degrees of inhibition. From the pathological point of view, on the rat vagina, cervix cavity exudate and loss of epithelial keratosis varying degrees of reduction in epithelial cell degeneration, necrosis and inflammatory cell infiltration, and other smaller groups of different levels, to promote the vagina, cervix recovery of inflammatory tissue, thus the vagina, cervix mucosa induce protection; have significant in vitro antibacterial effect; kill Trichomonas vaginalis in vitro experiments showed that Trichomonas vaginalis have a stronger role in killing. Ear swelling in mice have more inhibited (P<0.05); of the abdominal cavity of mice induced by acetic acid inhibited the increased capillary permeability; on the agar granuloma formation in mice inhibited; in hot plate, the pain threshold in mice significantly increased role; writhing in fuyankang effervescent suppository can prolong the incubation period of occurrence of writhing, writhing reduced by 20 minutes, the number of occurrences.The experimental study found that anti-inflammatory mechanism, fuyankang effervescent suppository suppress inflammation and reduce the inflammation and tissue content of PGE2 excited hypothalamus-pituitary-adrenal axis-related.Conclusion:Fuyankang suppositories on phenol glue-induced rat vaginitis, cervictis model treatment. Vaninal and cervical mucosa can reduce the mumber of inflammatory cells, size, and so on. To alleviate the pathological changes of inflammatory cells, and thus on the vagina. Cervix mucosa barrier function plays a prorective effect. And has significant anti-bacterial, anti-inflammatory, analgestic effect. By anti-inflammatory mechanism of experimental studies have shown that anti-inflammatory fuyankang mechanism of effervescent suppository play and reduce viginitis, cervictis and cervical tissue of rats with vaginal PGE2 content and excitement of hypothalamus-pituitary-adrenal axis function.