The Impact Of Tiao Zhi Decoction On The Patients With Stable Angina Clinical Efficacy And Lp (a),MMP-9,IMT

Objective:To study the efficacy and saftety of tiaozhi decoction, treating stable angina patients of(the congealing phlegm of heart vessels)and impact of LP(a),MMP-9,IMT, discuss a preliminary evaluation of its safety and effectiveness and part of its clinical mechanism.Methods:selected a total of 60 angina pectoris patients with the syndrome of the congealing phlegm ofheart vessels.were divided into two groups. The treatment group had 30 patiens who were given Tiaozhi decoction,The control group had 30 patiens who were given simvastatin.All the patiens were treated with two months. Cure and effictive rates in the two groups were evaluated .Duration of angina attack and ferquence were counted and measured; ECG; TCM; serum MMP-9,carotid artery IMT; TC,LDL-C,HDL-C,TG, Lp(a),Glucose, were measured regularly before study entry and close to the study respectively.Results:1.After treatment ,two groups of patients there has been a marked improvement,and in the treatment group compared with control group there was no significance difference(P>0.05).The treatment group with syptoms of angina,ECG effective rates were 96.67%,93.33% better than the control group93.33%,90.00%.2.TCM symptoms and signs such as chest pain, chest constriction, palpitation, breath shortness, fatigue,spontaneous perspiration were ameliorated significantly in both groups (P<0.01). No differents between two groups (P>0.05).3.The levels of CH,LDL,TG in both groups were lowered markedly (P<0.01) .But there have no difference between the two groups(P>0.05).4. The level of serum MMP-9 were lowered as compared with before treatment,indicating significantly differences(P<0.01); The carotid IMT and plaque score in both groups trended to decrease at the end of the study.There have no differents between two groups (P>0.05);The leve of lp(a) in the treatmen group trended to decrease at the end of the study,but in the control group did not, The treatmen group is superior to the control group(P<0.01). 5. No changes were found at at pre-and post-treatment in safety indexes of the both groups ,like routine tests of blood and urine hepatic function and renal function.Conclusion:1.Tiaozhi decoction can improved clinical symptoms of stable angina pectoris, decrease angina attack and frequency and TCM.2. Tiaozhi decoction can decrease the level of serum MMP-9 and Lp(a) in stable angina patients.3. Tiaozhi decoction can decrease carotid artery IMT, On a certain degree to prevent AS.