Research On Risk Factors Involved In Rupture Of Intracranial Aneurysms

Intracranial aneuryms is a limitation protrusions of abnormal tumor-like in cerebral artery, is the most common cerebral vascular diseases. The incidence is 4.05% in normal. The rupture rate is 1 % of unruptured aneurysm. The rupture of intracranial aneurysms is the most common cause that leads to subarachnoid hemorrhage. 8%～30% of patients died before treatment,but if the rupture occurs again, the mortality is 70%. Early correct diagnosis and treatment have important significance to reduce disability rate and mortality. CTA can rapidly diagnose intracranial aneurysms. Nowadays, treatment of aneurysms mainly depends on surgery, including Endovascular embolization of aneurysm and Clipping and ligation of the neck of aneurysm. With the development of medical science, the cure rate of aneurysm will be gradually improved.Objective:Improve surgical indications and surgical of the preoperative aneurysm in the preoperative. Analyze the rupture factors of intracranial aneurysm , improve the cure rate of patients.Methods:According to the retrospective analysing of 82 intracranial aneurysm patients in the Second Hospital of Jilin University from February 2009 to February 2011 , 102 aneurysms were detected,with 59 ruptured aneurysms,and 43 unruptured aneurysms included. Record gender, age, etc. Obtain data by CTA. Measure the depth,the maximum diameter and the neck width of each aneurysm, and record it whether there're ascus on aneurysms. Calculate the ratio of depth and neck width,Finally, statistical analysis is performed.Results:1.There is statistical difference between the rupture rates of aneurysms in different locations(χ2=19.186,P<0.05 ).2.Among 82 aneurysm patients, the number of female patients was 1.56 times more than that of males. There 're statistical difference between the rupture rates of female and male patients (χ2=13.612,P<0.05).3.There's statistical difference between mean max diameter of ruptured and unruptured aneurysm groups(u=2.817,P<0.05). There're statistical differences between rupture rates of maxi- mum diameter >10mm and maxi- mum diameter <10mm (χ2=4.343,P<0.05 ).4.There're statistical differences between mean depth of ruptured and unruptured aneurysm groups (u=4.447, P<0.05).There're statistical differences between mean neck width of ruptured and unruptured aneurysm groups(|u|=0.396,P>0.05).There're statistical differences between AR of ruptured and unruptured aneurysm groups (u=5.99, P<0.05).5.There're statistical differences between the ascus of ruptured and unruptured aneurysm (χ2=15.175,P<0.05).Conclusin:1.The locations of aneurysm is the risk factor that leading to burst.2.The incidence and rupture rate of aneurysm in women is higher than men. 3.There exist risk of rupture in maximum aneurysm diameter>10mm higher than maximum aneurysm diameter<10mm.There is also exist the risk of rupture in maximum diameter<10mm.4.The longer the length of the aneurysm, greater the AR value the more likely lead to rupture of aneurysm. Neck width of the aneurysm is not the risk factor that leading to aneurysm rupture.5.The existence of ascus is a high risk factor of rupture.