| Objective: To explore the role of thyroid hormone in the mechanism of type 2 diabetes, weanalyzed the correlation between the thyroid hormone changes and the insulin sensitivity indexin the patients with type 2 diabetes mellitus (T2DM).Methods: Ninty health people in check-up were recruited as control from the second hospitalshanxi medical university health medical center during December 2009 to December 2010. Itincluded 60 males and 30 femals. Age of this group ranged from 37 to 74 years and the mean agewas 56.2±9.7years. Meantime, 312 cases of type 2 diabetic patients were selected as case groupfrom endocrine division of the second hospital shanxi medical university during December 2009to December 2010. It included 207 males and 105 females. The age of this group ranged from 33to 90 years and the mean age was 56.9±9.7 years. Then, we define the criteria of recruitment forcase group as follows. Inclusion criteria:①After the oral glucose tolerance test (OGTT)screening, meet the 1999 world health organization (WHO) diagnostic criteria for type 2 diabetes.②According to our laboratory test standards, the thyroid function is normal. exclusive criteria:①the person who are using the drugs affecting the thyroid functionor have thyroid disease;②The patients with acute disease (such as myocardial infarction, serious infection, trauma in thelatest 3 months);③malignant tumor;④Pateints with serious heart, liver, kidney failure orhypertension;⑤the pregnant or in lactating;⑥patients with radiation exposure previously. Forall subjects, blood pressure was examined and FPG, FINS, FT4, FT3 and TSH were examinedafter overnight fasting for 12h. Glucose oxidase method and chemical luminescence were usedseparately to detect the level of FPG and FINS, then, ISI was calculated through the followingformula: ISI=1/FPG(mmol/L)×FINS(mIU/L). Solid-phase chemical luminescenceimmunoassay was used to measure the level of FT4, FT3 and TSH, followed by calculating theratio of FT3 to FT4. SPSS 17.0 software was used to perform the statistical analyses. When thedata from different groups were compared, normal analysis and homogeneity of variance werechecked first, and then an independent two-tailed t test analysis was used and the results wasshown as x±s. The relation of FT3/FT4 and ISI in the case group was carried out by Pearsoncorrelation. P <0.05 was considered significant.Result: 1. when compare the data of T2DM group with control, the level of FT3 wassignificantly lower (P < 0.05, but the level of FT4 is significantly higher; consequently, FT3/FT4is lower. There is no difference of TSH level between two groups; ISI in the T2DM group was higher than control (P < 0.05).2. the ratio of FT3 / FT4 was correlated positively with Ln(ISI) (r = 0.557 P < 0.05).ConclusionConclusion:1. In type 2 diabetics, FT3 reduced, FT4 increased and TSH show no changes when comparedwith normal conrol.2. In type 2 diabetics, the transformation from FT4 to FT3 was inhibited.3. In type 2 diabetics, the inhibition of FT4 to FT3 and reduced FT3 induced the lower sensitivityof insulin, which may reveal the mechanism of development of type 2 diabetes.
|
PDF Full Text Request