Anti-fibrosis Effect Of Du Yiwei Granule On Rats With Hepatic Fibrosis

Objective:To observe the anti-fibrosis treating effect of Du Yiwei Granule on rats with hepatic fibrosis, in order to research the Du Yiwei's efficacy, which can improve the function of hepatic cells, control the generation of hepatic lobule. To expound the mechanism of Du Yiwei's protecting effect on rats'livers, so as to provide modern scientific foundations on clinic treatments of hepatic fibrosis.Methods: Sixty Sprague-Dawley rats were randomized into six groups: normal group; model group; COL (Colchicine) group; high-dose,medium-dose,low-dose "Du Yiwei Granule" group, these rats hepatic fibrosis model were induced by CC14 oil combining high lipoid forage as control, simultaneously, gave administered treatment at the beginning of the experiment, normal group and model group were given NS equally, during the experiment time, observed the general situation of each group's rats carefully, then six weeks expired, prohibited food in 24 hours, took samples of rats'serum from thigh-artery to test hepatic function's indexes: ALT,AST,MAO, and hepatic fibrosis's indexes:PCⅢ,HA, at that same time, took liver tissue in equal quality from equal place to pathological slice and dyeing, then observed the pathological change of rats'livers.Results: Comparing the model group, each group can obviously reduce the rats'serum content in ALT,AST,MAO (P＜0.01), except the low-dose group of "Du Yiwei Granule" can reduce in that (P＜0.05); except the PCIII of medium-dose,low-dose "Du Yiwei Granule" group are inclined in some lever but have no statistical significance (P>0.05, the rest treated group all lower the rats' serum content in PCIII,HA (P<0.01); Comparing the model group, three groups of "Du Yiwei Granule", the declining degree of hepatic fibrosis is clearly (P <0.01). There have no obviously difference between COL group and three groups of "Du Yiwei Granule" (P>0.05)Conclusion:Du Yiwei Granule, can effectively relieve the pathological change of rats'liver, improve liver's function, decline the degree of hepatic fibrosis, which has a better anti hepatic fibrosis' efficacy.