The Value Of Serum Transferring Receptor In The Diagnosis Of Iron Deficiency In 6-mo To 7-yr Children

BackgroundIron deficiency (ID) is the world's most common single nutrient deficiency. Iron-deficiency anemia (IDA) in infancy is consistently associated with poorer cognitive, motor, and social-emotional outcome and altered neuromaturation, in the short- and long-term, even with iron therapy. Iron deficiency includes iron deficiency (ID) without anaemia and iron-deficiency anaemia (IDA).At present, hemoglobin (Hb) is usually adopted as screening index for iron-deficiency anaemia in clinic. Studies found that Hb is not a good index to predict iron deficiency. Hb can only screening anemia, but not ID. Thus, quite a number of children with ID cannot be timely discovered, and then develop IDA. Comprehensive and accurate evaluation of body iron status, timely diagnosis and early therapy of iron deficiency is the key to prevent and control IDA. Therefore, to explore a convenient, more sensitive and specific screening tool for iron deficiency, which is suitable for child health care system, would be extremely important for early diagnosis, prompt intervention and prevention of iron deficiency, and would optimize child development in motor, cognition and social emotion as well.AimTo investigate the incidence of iron deficiency in children 6 months to 7 years of age in this study, and evaluate the diagnostic value of serum transferring receptor(sTfR) in iron deficiency of children. MethodsUsing Diagnostic Method, total 502 healthy children aged 6 months to 7 years old participated in the study from Hangzhou area. sTfR,SF, Serum iron(SI), Total iron blinding capacity (TIBC), zinc protoporphyrin (ZPP).Hb.MCV and CRP levels were measured.Statistical methods:One-way AN OVA,chi-square test and receiver operating characteristic(ROC)curve have been used in the study. Correlation Analysis and Regression Analysis were used to explore sTfR that relate to the other diagnose indexes applied in iron deficiency.Results1. Iron deficiency happened 20.1%(ID16.9%, IDA 3.2%)in all of children aged 6- mo to 7-yr, it is the most common in infants((?)1y) (ID25.0%, IDA 12.5%), followed by toddlers (1y