The Effect Of Xin Naotongluo Solution On T-PA And PAI-1 Of Acute Cerebral Ischemia In Rats

Objective:To study and evaluate the effect of Xinnaotongluo-solution on t-PA and PAI-1 of acute cerebral ischemia in rats, to provide experimental basis for clinical treatment of acute cerebral ischemia.Methods:Healthy SD rats,to be divided into five groups:cerebral ischemia group(model group), Xinnaotongluo-solution high-dose group (high-dose group), Xinnaotongluo-solution low-dose group (low-dose group), BuChang-Naoxintong in the control group (control group), sham-operation group(sham group).Establish the MCAO model of focal acute cerebral ischemia in rats, and the test change of contents of t-PA,PAI-1at 6h,12h,24h after operation.Results:1. The effect of Xinnaotongluo-solution on PAI-1 activeties of cerebral ischemia in rats:compared with the sham group,6h after cerebral ischemia,the activeties of PAI-1 in model group began arising,while the highist point appeard at 24h(p<0.01).The activeties of PAI-1 in all the treatment groups are lower than model group,especially the high-dose group(P<0.01).2. The effect of Xinnaotongluo-solution on t-PA of cerebral ischemia in rats:compared with sham group,6h after cerebral ischemia,the content of t-PA in model group began reducing,while the lowest point appeard at 24h(p<0.01).The content of t-PA in all the treatment groups are lower than model group,especially the high-dose group(P<0.01).Conclusion:1. Xinnaotongluo-solution can significantly rise PAI-1 activeties of acute cerebral ischemia rats,And to the inhibition of the damages caused by oxidative free radicals,protecting nerve cell.2. Xinnaotongluo-solution can rise the content of t-PA which secreted by body, to achieve its neuroprotective effect in actute cerebral ischemia, and effectively to reduce the focal cerebral ischemic injury.