Epidemiology Study On Risk Factors Of Fatty Liver Among Entry-Exit People

Objective The present study was conducted to investigate the current situation and risk factors of fatty liver, and to provide the scientific evidence for disease control and prevention against fatty liver.Methods Body height, weight and blood pressure were measured, and liver examination was done by using B Mode Ultrasound, fasting plasma blood, plasma lipid, blood urea nitrogen (BUN), creatine (CREA), uric acid (UA) and other biochemical parameters were examined for entry-exit people in Kunshan city, from January 1,2008 to October,31,2008. The relationships between body mass index (BMI), biochemical parameters and the risk of fatty liver were analyzed. Results Among 4 237 subjects, the number of patients who suffered from fatty liver was 910, and the prevalence of fatty liver was 24.78%. The age, male ratio, BMI, SBP, DBP, TC, TG, HDL-C, LDL-C, GLU, UA, BUN and CREA in the subjects with fatty liver were all higher than those without fatty liver.Compared to those with BMI<25.0, the OR of fatty liver tend to ascent with increasing of BMI, no matter adjusted for multivariable or not, and subjects with BMI >28 was associated with 16-fold higher odds of fatty liver.Compared to those with DBP<90, the ORs and 95% CI of fatty liver for subjects with DBP of 90-99mmHg and≥100mmHg were 1.60(1.27,2.02) and 1.51(1.06,2.16), respectively.Compared to those with TG<0.97mmol/L, the ORs (95% CI) of fatty liver for subjects with TG of 0.97-,1.33-and 1.95-were 1.46(0.99,2.13),1.79(1.23,2.61) and 2.43(1.64,3.60), respectively. After adjusted for multivariable, elevated TG might increase the risk of fatty liver.Compared to those with HDL-C<0.86 mmol/L, the ORs (95% CI) of fatty liver for subjects with HDL-C of 0.86-,0.98-and 1.14-mmol/L were 0.80(0.63,1.01),0.58(0.44, 0.76) and 0.59(0.42,0.83), respectively. High HDL-C was inversely related to the risk of fatty liver.Compared to those with LDL-C<2.36 mmol/L, adjusted ORs (95%CI) fatty liver for subjects with LDL-C of 2.36-,2.87-and 3.29-mmol/L were 1.08(0.77,1.53), 1.21(0.81,1.81) and 1.72(1.10,2.69), respectively. High level of LDL-C increased the risk of fatty liver.Compared to those with UA<252.7 mmol/L, adjusted ORs (95% CI) of fatty liver for subjects with UA of 252.7-,318.0-和380.7-mmol/L werel.35(0.92,1.96), 1.35(0.93,1.97) and 2.31(1.59,3.36), respectively. The risk of fatty liver increased as the increasing of UA.Conclusion Overweight, hypertension, high TG, low HDL-C, high LDL-C, high FPG and high UA were the risk factors of fatty liver.