Dynamic Analysis Of Laboratory Results Of High-risk Groups For Liver Cancer In Guangxi Communities And Detection Of Non-alcoholic Fatty Liver

Objectives: To establish a cohort of hepatitis B surface antigen and high-risk core antibody-positive individuals in a community in Guangxi,and collect general data of the follow-up patients to understand the changes in demographic composition during follow-up.The laboratory data and color ultrasonography results of the follow-up were collected.Analytical laboratory results included dynamic changes in transaminase and bilirubin during follow-up.The status of non-alcoholic fatty liver in the follow-up population was analyzed and related risk factors were analyzed.At the same time,the differences in the types of hyperlipidemia between non-alcoholic fatty liver patients and non-alcoholic fatty liver patients were analyzed.Methods:The follow-up results of seven follow-ups from a high-risk liver cancer cohort from a community in Guangxi from April 2011 to December 2016 were selected.The survey registration form was used to collect general data for all followers.After 12 hours of fasting,blood was collected for the detection of five hepatitis B items,alanine aminotransferase,aspartate aminotransferase,total bilirubin,direct bilirubin,indirect bilirubin,triglyceride,cholesterol,and fasting blood glucose.Hepatic color Doppler ultrasonography was used for imaging diagnosis of patients with non-alcoholic fatty liver disease.The clinical diagnostic criteria were based on the ?Guide to the diagnosis and treatment of nonalcoholic fatty liver disease?.The results of the 7 follow-ups were collated,data were stored using excel and Epidata software,and statistical analysis was performed using SPSS17.0.Results:Among the seven follow-up participants who participated in the cohort of high-risk liver cancer in a community in Guangxi,the number of people who participated in the fifth follow-up was the highest,which was 1369.The gender composition was dominated by males,and the percentage of males in the follow-up population gradually increased with time.The proportion of abnormal transaminase among the number of follow-up patients fluctuated between 24% and 44%.The number of transaminase abnormalities accounted for 43.53% at the 1th follow-up.The highest proportion of bilirubin abnormalities occurred at the fourth follow-up,which was 10.51%.The detection rate of NAFLD in 7 visits fluctuated between 7% and 15%,showing a slow growth trend.Among them,TG,TC,and FPG were the risk factors for NAFLD,and the risk levels from high to low were TG>TC>FBG.There is a difference in the type of hyperlipidemia between NAFLD patients and non-patients.NAFLD patients are mainly composed of a mixture of TG and TC,while non-NAFLD patients are mainly high-TC.Conclusion:Among the seven follow-up participants who participated in the cohort of high-risk liver cancer in a community in Guangxi in the past seven years,the gender composition was dominated by men.Abnormal transaminase and abnormal bilirubin have no obvious time trend.However,the detection rate of NAFLD showed a slowly increasing trend.The occurrence of NAFLD was related to TG,TC,and FBG.The risk of NAFLD was higher in high-TG,TG and FBG patients.The type of hyperlipidemia in patients with NAFLD is mainly mixed type,and non-patients are mainly high-TC alone.