| Objectives Through the inhalation of lavender, ylang ylang essential oils to observe the two kinds of pairs of normal and hypertensive patients with blood pressure, combined with lack of sense of smell to explore oil group pathways regulating blood pressure and its possible mechanism of lowering blood pressure to find new material and the role of channels, Auxiliary control of blood pressure for clinical disease clinical trial provides the basis.Methods In this study population by first selecting health check before the experiment using modified chemical senses the state of Connecticut Clinical Research Center (CCCRC) method of testing were divided into normal group and the sense of smell loss group. The normal group and the sense of smell sense of smell in the missing group of normal subjects No. 1d, No. 2d, respectively, the first 3d inhaled distilled water, lavender essential oil and ylang ylang essential oils, using cuff method according to Korotkoff sounds I, sustain and section V (disappearance of sound) to determine SBP and DBP, average of three consecutive blood pressure measurement allowed a free choice. The normal group and the sense of smell sense of smell loss in patients with hypertension group inhaled lavender essential oils and distilled water, respectively, using 24h ambulatory blood pressure monitoring instrument for monitoring blood pressure. Radioimmunoassay using human inhalation of essential oils before and 30min after inhalation of blood plasma renin activity (PRA), angiotensin I (AngI), angiotensin II (AngII) and aldosterone (ALD) levels. Results1. Normal sense of smell after 10min inhalation of lavender essential oil SBP, DBP, and MAP were started to decline after inhaling 20min, 30min, 1hSBP, DBP, and MAP decreased with the inhalation earlier differences were significant, inhalation ylang ylang essential oils and distilled water after the SBP, DBP, and MAP there was no significant difference in change; inhalation of lavender essential oil and distilled water inhalation after 20min, 30min, 1 hour SBP, DBP, and MAP decrease was significant difference between the inhalation of lavender essential oil and ylang ylang essential oils inhalation after 20min, 30min, 1 -hour SBP, DBP, and MAP decreased the difference was significant; inhaling ylang ylang essential oils with the inhalation of distilled water, after 20min, 30min, 1 hour SBP, DBP, and MAP was no significant .2. Missing group inhaled normal sense of smell lavender essential oil, ylang ylang essential oils and distilled water after the SBP, DBP, and MAP was no significant difference in change. Normal sense of smell after 10min inhalation of lavender essential oil SBP, DBP, and MAP were started to decline after inhaling 20min, 30min, 1h SBP, DBP, and MAP decreased compared with the sense of smell loss were significantly difference.3. Sense of smell normal group 30min after inhalation of lavender essential oil absorption in plasma PRA, AngI, AngII, and ALD and inhalation earlier to reduce the difference was statistically significant (p <0.05), inhalation of ylang ylang essential oils and distilled water before and after absorption 30min plasma PRA, AngI, AngII and ALD was no significant difference (p> 0.05). 30min after the inhalation of lavender essential oil the same time, plasma PRA, AngI, AngII, and ALD and 30min after inhalation of distilled water and there was significant difference (p <0.05), inhalation of ylang ylang essential oils with distilled water and 30min after the plasma PRA, AngI, AngII, and ALD was no difference significant (p> 0.05). The sense of smell normal group 30min after inhalation of lavender essential oil absorption in plasma PRA, AngI, AngII, and ALD group compared with the sense of smell loss were significantly difference (p <0.01).4. Normal sense of smell in patients with hypertension after 30min inhalation of lavender essential oil SBP, DBP, and MAP decreased after inhaling 30min, 1h -5h SBP, DBP, and MAP decreased with the smoke earlier differences were statistically significant 6 hours after the blood pressure before the trial to resume level. After the inhalation of distilled water and SBP, DBP, and MAP there was no significant difference in change; inhalation of lavender essential oil with distilled water inhalation after 30min, 1h -5h SBP, DBP, and MAP decreased with the smoke earlier differences were significant. Anosmia group of patients with hypertension after inhalation of lavender essential oil SBP, DBP, and MAP was no significant difference in change. Normal group, inhalation of lavender essential oil smell after 30min, 1h -5h SBP, DBP, and MAP decreased compared with the sense of smell loss were significantly difference.5. Normal sense of smell in patients with hypertension after inhalation of lavender essential oil suction 30min plasma PRA, AngI, AngII, and ALD and inhalation earlier to reduce the difference was statistically significant (p <0.05), inhalation of distilled water before and after absorption 30min plasma PRA, AngI, AngII and the ALD was no significant difference (p> 0.05). 30min after the inhalation of lavender essential oil plasma PRA, AngI, AngII, and ALD and 30min after inhalation of distilled water and there was significant difference (p <0.05), olfactory dysfunction in patients with hypertension group inhaled lavender essential oils and distilled water, 30min before and after the plasma PRA, AngI, AngII and ALD, and inhalation of the former was no significant difference (p> 0.05).6. Gas chromatography - mass spectrometry (GC-MS) analysis of lavender essential oil, were identified 29 kinds of chemical components, the main ingredients of linalyl acetate (25.54%), linalool (25.49%), diethyl phthalate (8.37 %), Neryl acetate (4.03%) and linoleic acid (3.82%).Conclusions1. Lavender essential oils through the olfactory pathway to reduce healthy SP, DP, MAP, and the pulse unchanged; ylang ylang essential oils through the olfactory pathway in healthy blood pressure and pulse remained unchanged.2. Healthy people with normal sense of smell after inhalation of lavender essential oil peripheral PRA, AngI, AngII, and ALD and decreased to lower blood pressure may be the peripheral mechanisms of action, ylang ylang essential oils do not have this effect;3. Lavender essential oil to reduce the sense of smell through the olfactory pathway in hypertensive patients with normal SP, DP, MAP, pulse no change;4. Normal sense of smell in patients with hypertension after inhalation of lavender essential oil peripheral PRA, AngI, AngII, and ALD and decreased to lower blood pressure may be the role of peripheral mechanisms; 5. Gas chromatography - mass spectrometry (GC-MS) analysis of the main component of lavender essential oil Linalyl acetate (25.54%), linalool (25.49%), diethyl phthalate (8.37), Neryl acetate (4.03 %) and linoleic acid (3.82%).
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