Clinical Significance Of Detection For Serum Of CEA,NSE,CYFRA21-1 In Senile Patients With Lung Cancer

BackgroundWith the aging of the world's population,Elderly lung cancer incidence and mortality have also significantly increased. Lung cancer have the following characteristics: highly malignant course, rapid development, the lack of its early specific symptoms and signs are lack, vulnerable to recurrence and metastasis, Lung cancer is highly malignant course of disease characterized by rapid development,and its early specific symptoms and signs are lack, and easy to recurrence and metastasis, so that early diagnosis of lung cancer in the elderly has become an important topic in geriatrics.Tumor Markers test is a simple, relatively low-cost, no side effects, etc, and thus it is more easily be accepted, especially for elderly patients. At present, some research about tumor markers in early diagnosis of cancer,determining Prognosis and prognosis of the research progress has been made, and many reports of its clinical value were investigated. In order to further evaluation and comparison of tumor markers'application in lung cancer in the elderly。In the last few years we have combined detection of serum carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), Cytokeratin 19 frage-ments (CYFRA21-1) levels to explore whose value in the elderly diagnosis and prognosis of lung cancer.ObjectiveDiscussing the relation between detection for serum of CEA,NSE,CYFRA21-1 and patient's age and analyzing the three index's characteristic in different age groups, different pathological type and different TNM stages, to evaluate whose Value on auxiliary diagnosis in senile patients with lung cancer. MethodsDetermining 455 cases of lung cancer, 382 cases of benign lung disease patients'CEA, NSE, CYFRA21-1,and analysis characteristics in different age groups, different pathological types, different TNM staging.Determine CEA in serum with electro-chemiluminescence immunoassay , NSE and CYFRA21-1 in serum with immunoradiometric assay.Results1.The three indexes level of lung cancer patients are obviously higher than lung benign disease patients'(BLD)(P<0.01), in which CYFRA21-1 level of senile patients with lung cancer groups are higher than non-senile groups'(P<0.01).2.In same age group, CEA,CYFRA21-1,NSE level of serum of adenocarcinoma , squamous carcinoma and small cell carcinoma groups tested is respectively higher; there is statistics significance on the differences of adenocarcinoma patients's CEA and squamous carcinoma patients's CYFRA21-1 among different age groups (P<0.05).3.Compared to each single item, diagnostic efficiency of the joint detection of three indexes of lung cancer is remarkably improved, and there is no difference among different age groups.4.Positive rate of tumor markers in same age group is increased along with the rise of clinical stages, positive rate of IV stage suffers'CEA and NSE are clearly higher thanⅠ+Ⅱstage suffers', there is statistics significance on the differences(P<0.05). There is no difference statistics significance between positive rate of IV andⅠ+Ⅱs tage suffers'CYFRA21-1(P﹥0.05). Joint detection is higher than single item, the difference is prominent (P<0.01), among age groups, there is statistics significance on detection difference among CYFRA21-1 onⅢstage and joint diagnosis (P<0.05). ConclusionSerum tumor markers CEA, NSE, CYFRA21-1 have important reference value in diagnosis, pathological type, stage and prognosis of lung cancer. provides an important reference value, and the relevance of elderly patients is more closely; three serum tumor markers have some overlap and complement each other between cell types of lung cancer, the joint detection is superior to single test , which can improve the positive detection rate of snile lung cancer's early diagnosis.