The Pharmacodynamics Research Of Eucommia Ulmoides Male Flower Tea

Eucommia ulmoides male flower tea is accepted by more and more people as a kind of new health drink, but now there is little report about Eucommia ulmoides male flower tea home and abroad. In 2001 Hongyan Du applied eucommia ulmoides male flower tea to be an inventive patent, and beginned to study in depth. The pharmacodynamics of eucommia ulmoides male flower tea is researched in this thesis, and it provide a basis of pharmacology and experiment for it is to be a kind of new health and safe drink, and to explore pharmacological action of eucommia ulmoides male flower tea. This thesis is composed of three chapters.Chapter I Consults massive literature home and abroad, overview the researching-development of Eucommia's chemical composition and the pharmacological action and the research present situation of eucommia ulmoides male flower tea. The chemical composition of eucommia ulmoides has research present situation, iridoids, the benzene third element class carbohydrates, gutta percha, flavonoids, amino acids, vitamin, microelement, eucommia ulmoides mycoprotein, evaporability elem and fatty acid; the main pharmacological action has the voltage dropping, the adjustment blood fats function, the bone cell multiplication function, the enhancement immunity function, the anti-tumor, the oxidation resistance, the antibacterial anti-viral function, anti-weary and injury the function, as well as advantage gallbladder, diuresis and fetus protection function. The chemical composition of eucommia ulmoides male flower tea is similar with eucommia ulmoides, but has differed content, now has little the research of ucommia ulmoides male flower tea's pharmacologic action.Chapter II The experiment is studied from from the seven aspect pharmacologic action of eucommia ulmoides male flower tea.1. The influence of Eucommia ulmoides male flower tea on the rat of high-sodium dietTo make the model of high blood pressure by high-sodium diet, after 8 weeks determine the blood pressure of the rat's caudae. In comparion with the model group both Eucommia ulmoides male flower tea high and low group could depress the rat's blood pressure which is caused by high-sodium diet (P< 0.05).2. Regulation Effects of Eucommia ulmoides male flower tea on Lipid Parameters of Mice Fed High Fat EmulUse High Fat Emul to make the model of hyperlipemia mice, after administering 30 days, to get blood from fossa orbitalis, segregate the blood serum, determine index. Hyperlipemia modle group mice serum TC, TG, LDL-C step up and HDL-C step down in comparion with the control group. And it was found different in high dose group mice'serum in comparion with hyperlipemia modle group. Eucommia ulmoides male flower tea has a certain precaution action on mice'blood-fat caused by high fat emul.3. Anti-aging effects of Eucommia ulmoides male flower tea on aging model mice inducedAging mouse model was induced by injecting subcutaneously D-galactose. The content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in blood serum and liver were tested. Eucommia ulmoides male flower tea could increase SOD and GSH-Px activities and decrease the content of MDA significantly. Eucommia ulmoides male flower tea has certain anti-oxidative and anti-aging effects by reducing free radical and MDA.4. Anti-stimulation effects of Eucommia ulmoides male flower tea on miceTo study the effects of Eucommia ulmoides male flower on ability of anti-stimulation of mice. The mice were divided into four groups atrandom, control group, Eucommia folium control group, high dose group and low dose group, administration by gastric perfusion on design dose 14 days. Observing the impact on anti - stimulation action by mice's common lower temperat ure-resistant test higher temperat ure-resistant test swimming test and anti-anoxia test ,and record the alive time. Eucommia ulmoides male flower took on the remark anti - stimulation action in the different dosages, Effectively extend the time of mice's common lower temperat ure-resistant higher temperat ure-resistant swimming and anti-anoxia.5. Mitigate and hypnotize effects of Eucommia ulmoides male flower tea on mice Administration by gastric perfusion on design dose 14 days, record the ambulation frequency in 5 minute after the last administration 15min,30min,60min. Use the same method, after the last administration inject Pentobarbital intraperitoneally 40mg/kg, then record the hours of sleep and hypno-delitescence. Eucommia ulmoides male flower tea could reduce the mice's ambulation frequency, and prolong the hours of sleep, shorten hypno-delitescence which is caused by Pentobarbital.6. Anti-inflammatory effects of Eucommia ulmoides male flower tea on forced foot of rat caused by albumenBefore experiment mark the right ankle of rat's immersion bouncary, measure and record every rat's drainage volume. Administration by gastric perfusion on design dose 14 days, after the last administration 30min, inject subcutaneously fresh albumen rat's left- aboral sole of foot 0.1ml, measure the drainage volume after administration 1 h, 2 h, 4 h, 6 h. Eucommia ulmoides male flower tea group could inhibit predominance forced foot of rat caused by albumen.7. The protection of Eucommia ulmoides male flower tea on mice's Hepatic injury caused by CCl4Administration by gastric perfusion on design dose 14 days, after the last administration inject subcutaneously CCl4, determin the contents of blood serum AST, ALT. Eucommia ulmoides male flower tea group could refrain the contents of mice's blood serum AST, ALT.Chapter III discuss the experiment in chapter II...