Relationship Of The Adiponectin Genotyping Of SNP+45 With Primary Hypertention In Yanbian District

Objective To evaluate the adiponectine genetyping of SNP+45 and the law of allele distribution in Chinese-Korean population and Chinese population through detect the frequency of adiponectine genotyping of SNP+45 and allele. Thus, investigate the relationship of SNP+45 and the level of plasma adiponectin with primary hypertention.Method There were 294 Chinese-Korean and Chinese peoples divided into Hypertention and Control group who were in Department of Cardiology, Yanbian Hospital from June 2008 to December 2009. Primary hypertention were diagnosed according to the 2005 ACC/AHA Guideline of Hypertention. Secondary hypertention, coronary heart disease, diabetes, heart failure, renal failure, cerebral artery disease, thyrotoxicity was rule out. Blood pressure, height, body weight, waist circumference, body mass index were routinely measured. Blood glucose, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein were also tested. The level of adiponectin was tested with ELISA method; Gene type and the frequency of allele was analysed with TaqMan assay.Result 1,Adiponectin genotyping of SNP+45 and distribution of allele in hypertention group was significantly difference with those in normal control group in Chinese-Korean and Chinese people in Yanbian district (P<0.05). Nevertheless, adiponectin genotyping of SNP+45 and distribution of allele in each hypertention grade was no significant difference. Adiponectin genotyping of SNP+45 and distribution of allele in Chinese-Korean with Chinese people in both hypertention and control group was no significant difference.2,The level of plasma adiponectin in hypertention group was lower than control group both in Chinese-Korean and Chinese people. Nevertheless, the level of plasma adiponectin in each hypertention grade was no significant difference. The level of plasma in Chinese-Korean with Chinese people in both hypertention and control group was no significant difference.3,The level of adiponectin in the people who have genotype of T/G+G/G was lower than the people who have genotype of T/T in Chinese-Korean and Chinese people.4,Age, sex, waist circumference, body mass index, high density lipoprotein in Chinese-Korean with Chinese people in both hypertention and control group was no significant difference. Smoking, systolic pressure, diastolic pressure, triglyceride, total cholesterol, low density lipoprotein, glucose in hypertention group was singnificantly higher than those in control group. Basic characterics and biological index in Chinese-Korean with Chinese people in both hypertention and control group was no significant difference. The level of plasma adiponectin in Chinese-Korean with Chinese people in hypertention group was positively related with waist circumference, body mass index, systolic pressure, diastolic pressure, glucose, total cholesterol, and triglyceride. The level of plasma adiponectin in Chinese-Korean with Chinese people in control group was negatively related with waist circumference, body mass index, systolic pressure, diastolic pressure and triglyceride.Conclusion 1,SNP+45 genotype of the secondary extron of adiponection in Chinese-Korean and Chinese people in Yanbian district was related with primary hypertention.2,The level of plasma adiponectin in Chinese-Korean and Chinese people in Yanbian district was related with the level of blood pressure.3,The level of plasma adiponectin in the people who have genotype of T/G+G/G was lower than those in the people who have genotype of T/T, indicated that the different genotype should affect the level of adiponection.4,There was no significant difference of SNP+45 genotype of the secondary extron of adiponection in Chinese-Korean with Chinese.