| Backgroud:As China's economic development, longevity, with the aging of society trends and changing lifestyles, the incidence of coronary heart disease and mortality was also an upward trend, a serious threat to people's lives and quality of life. In recent years a large number of laboratory and clinical evidence have proven that chronic inflammation is the occurrence of atherosclerosis, an important mechanism for the development of inflammatory response in the pathogenesis of coronary artery disease plays an important role. Elderly patients are a special category of people, often at the same time as coronary heart disease with multiple organ disease, poor tolerance of drugs. Chinese medicine has fewer side effects, security, etc.Objective:Yi Qi Huo Xue Qu Tan Fa observational study in elderly patients with coronary heart disease symptoms and treatment before and after the CRP, IL-6, TNF-α, the change of Qi. and activating blood circulation and removing phlegm to coronary heart disease and prognosis of inflammatory indicators.Method:A prospective randomized controlled clinical trial options. Selection into the diagnostic criteria for coronary heart disease patients found a total of 60 cases were divided according to the ratio of 1:1 composition of the treatment group and control group, the treatment given on the basis of conventional Western medicine and then were given Yiqihuoxue expectorant medicine (Wendan Tom xuefuzhuyu Decoction) and treated for 4 weeks. Before and after the observation in the treatment of angina, ECG effects, Chinese medicine symptoms, blood lipid (TC. TG, LDL, HDL), inflammatory markers C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor (TNF-α) and quality of life (SF-36 and SAQ) changes.Result:Angina pectoris:After treatment, the treatment group, the total effective rate was 90%, significantly higher than the control group 63.3%, a significant difference between the two groups (P<0.05).ECG:electrocardiogram treatment group and control group the total effective rate was 86.7% and 76.7%, but showed no significant difference (P> 0.05). Chinese medical symptoms curative effect:symptom score in both groups were significantly improved (P<0.05), especially in the treatment group improved significantly less than the control group (P<0.01). Traditional symptoms of clinical efficacy total effective rate was 86.7%, significantly higher than the control group 63.3%, a significant difference between the two groups (P <0.05).Lipid levels:After treatment, the treatment group cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) decreased significantly (P <0.05), the control group decreased but not significantly different (P> 0.05), compared with the control group after treatment, there were significant differences (P<0.05). Treatment group, high-density lipoprotein (HDL) Notwithstanding the increase, but no significant difference (P> 0.05), compared with the control group decreased, and no clinical significance (P> 0.05), treatment group than the control group.CRP, IL-6, TNF-αchanges:After the treatment group CRP, IL-6 are significantly lower, there were significant differences (P<0.05). Numerical control group decreased but not significantly different (P> 0.05). TNF-αtreatment group and control group values decreased in both groups were significantly different (P<0.05), but the treatment group decreased at lower values, the treatment group than the control group.Quality of life changes:the quality of life (SF-36) Form score in the treatment group and control group after 4 weeks in the treatment of physiological function, general health, energy, emotional function, mental health, health change in the significantly changed, statistically significant (p<0.05), treatment group, physiological function, general health, mental health change more obvious, there are statistically significant (p<0.01); in physical function, bodily pain, social ability, the treatment group statistically significant (P<0.05), the control group was not significant (P> 0.05), treatment group than the control group. Seattle Inventory (SAQ) scores, treatment group and control group after treatment scores were significantly higher than before treatment scores was statistically significant (P<0.01).Conclusion:Yiqihuoxue expectorant method can effectively improve the clinical symptoms in patients with coronary heart disease, especially in clinical symptoms and the symptom score improvement was better than western medicine group, has good clinical efficacy. Can reduce TC, LDL, TG, increased HDL's role, while certain anti-inflammatory effects, and can significantly reduce CRP levels, and inhibit IL-6, TNF-αrelease, so be part of the restoration of damaged blood vessels. Same physiological function in patients with coronary heart disease, body pain, social skills and so improve the more evident.
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