| Objective:By using rabbit cisterna magna injection of tracers to verify the hypothesis lymphatic drainage of cerebrospinal fluid; of communicating hydrocephalus etiology, risk factors, diagnosis and treatment; of Ways and lymphatic drainage of cerebrospinal fluid of unknown causes hydrocephalus associated traffic , try to explain some of the reasons for communicating hydrocephalus of unknown path physiological basis.Method:On 20 healthy rabbits were pure cisterna magna after injection of Chinese ink, executed after the observation of bilateral neck superficial and deep lymphatic vessels, and take some sieve Department olfactory mucosa biopsy, HE stain, were observed in the microscope and camera ; retrospective analysis from January 2006 to December 2009 in the Sino-Japanese Friendship Hospital, Jilin University, 24 cases were treated cases of hydrocephalus etiology, risk factors, diagnosis and treatment; literature review attempts to explain some of the traffic of unknown causes the basis of the path physiology of hydrocephalus.Results:After the cisterna magna gross and microscopy, rabbit bilateral neck superficial and deep lymphatic vessels within the olfactory bulb, sieve plate and the nasal mucosa, superficial cervical lymphatic system, lymphatic system, the deep cervical specimens was observed black; in olfactory mucosa of the lower scattered within the lymphatic vessels have more ink distribution, and in the artery and vein did not see the ink, these results demonstrate the hypothesis of lymphatic drainage of cerebrospinal fluid; unknown communicating hydrocephalus and cerebrospinal fluid return means there is a certain correlation, pending further experiments verification.Conclusion:Rabbit cisterna magna cerebrospinal fluid injection of contrast medium verified the hypothesis of lymphatic drainage; CSF lymphatic drainage channels and idiopathic communicating hydrocephalus correlated, could explain some of the reasons for communicating hydrocephalus of unknown path physiology of the specific pathways need to be further experiments. |
