Effects Of Simvastatin On The Proliferation And Collagen Systhesis Of Human Nasal Polyps Fibroblasts

Objective: To investigate the effects of simvastatin on the proliferation,collagen excretion of human nasal polyps fibroblasts(NPFs).Methods: Human nasal polyps fibroblasts(NPFs) were isolated and cultured.Nasal polyps fibroblast proliferation was measured by WST-8 Cell counting (CCK-8)assay.Collagenâ…¢in the condtioned media was determined by ELISA..Results:SIM (0.1,1,10,100 umol / L) on the impact of the growth of human NPF with different time (48h, 96h, 144h) come up with different results. 48h with various concentrations of SIM can not inhibit the growth of NPF. The extension of time (96h, 144h) With SIM (1,10,100 umol / L) , SIM can inhibit the NPF growth. CCK-8 colorimetric Am values showed decreasing trend, with the control compared, the differences were significant (all P