| Objective:To study the expression of a new type of CD4+ effector cell-T help 17 cell and the related immunology cytokines in allergic rhinitis patients,and explore the function of Th17 cell in the allergy rhinitis pathogenesis, to provide a foundation for further studying on Th17 cell function regulation mechanism.Method:30 allergic rhinitis patients with inferior turbinate hypertrophy or nasal polyps as a case group,25 deviation of nasal septum patients with inferior turbinate hypertrophy as normal control group.During the endoscopic nasal, nasal mucosa were obtained, in which the expression level of Th17 were detected by the immunohistochemistry SP and the expression level of IL-17,TGF-βwere detected by ELISA.In the end,we drew a conclution through statistical analysis.Result:1. the average level of Th17 positive cells in the allergic rhinitis patients and control group has significant differences (P<0.001); the expression of Th17 is high in allergy rhinitis patient nose mucous and is low in the control group nose mucous.2.the expression level of IL-17 in the allergic rhinitis patients and control group has significant differences (P<0.001); allergic rhinitis patients express high compared with the control group.3. there is a positive correlation between Thl7 and TGF-βin the Allergic rhinitis patients (P＜0.001).Conclusions:1.In the allergy rhinitis patients, the high expression of Th17 cell may be a very important reason.2. TGF-βmay synergistic Th17 cells to involve in the occurrence and development of the allergic rhinitis.3. In allergy rhinitis, there have close correlations between the levels of Th17 cell and TGF-β, which perhaps may provide a new mentality for the allergy rhinitis's treatment.
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