Primary Research Of The Emotional Memory In Patients With Leukoaraiosis

Objective Leukoaraiosis(LA)as one of small vascular disease get more and more attention and study,Now most study has shown LA affect cognitive function.This study used different valence images(including positive,neutral and negative pictures)to investigate the emotional memory characteristic in patients with Leuloaraiosis(LA)and healthy,exploring the neurobiological mechanisms undellying though emotional memory tasks involving different valance of emotional pictures.Subject and methods Selected patients whom see neurology clinic of outpatient and hospitalization in the Third Affiliated Hospital of Anhui Medical University btween July 2015 and February 2016,twenty-four patients with Leuloaraiosis(LA group)and twenty-four healthy colltrols(HC group)respectively test on magnetic resonance imaging(MRI)scan and mental state scale(MMSE),span including word fluency test(Verbal fluency test,VFT),digit span test(digital span,DS),Hamilton anxiety scale(HAMA)and Hamilton depression rating scale(HAND)testing of neuropsychological tests,using different valence images(including positive,neutral and negative pictures)to evaluate the status of cognitive function,and using the criteria of Fazekas to divid LA severity into 3 level(light,medium,heavy),which analysis cognitive impairment correlation between LA patients and the severity of disease.Results There are no statistical significance between LA and HC in age,level of education,as well as the background of neuropsychological test(p > 0.05).In appraisal of the emotional pictures..There were no significant difference between patients with LA[positive(10.42±2.30)and neulral(12.87±2.29),respectively] and healthy controls[positive(11.38±3.25)and neutral(12.75±2.86),respectively] in positive and negative appraisal(p>0.05).But the negative appraisal had decreased between LA(11.63±1.81)and healthy control(12.75±2.02)(p>0.05).Compared with healthy controls(39.83+±5.73),patients with LA(33.67±7.10)showed sharply decline in the emotional images memorizing task(p<0.05).And the accuracy in recognizing positive and netural valence pictures in patients with LA[(positive(11.04±2.40)and neulral(10.42±2.93),respectively]were significantly lower than those in healthy controls [positive(12.79±2.17)and neutral(12.08± 2.59),respectively ](P<0.05).But in negative stimulus,there was no significant difference between LA group(13.20±1.86)and HC group(12.20±2.65)(P>0.05).In addition,the negative appraisal,the correct recognition,positive and neutral valence in pictures recognition were negativly correlated with the severity of white matter lesions in the LA patients group(r=-0.308,p=0.033;r=-0.308,p=0.033;r=-0.426,p=0.003;r=-0353,p=0.014).Conclusions The results show that LA patients is closely related to cognitive function.the negative appraisal is impaired in appraisal of the emotional pictures.Meanwhile,the emotional memory for positive and neutral vanlence pictures are impaired but the emotional memory for neutral is relatively reserved in patients with Leuloaraiosis in pictures recognition phase..Furthermore,the emotional memory is impaired in patients with LA.And increasing by the severity degree of LA The results also suggest that impaired emotional memory with different valences may relate with different neuromechanisms.