The Clinical Effect On Prevention Of Glucocorticoid Osteoporosis With The Therapy Of Nourishing The Kidney And Strengthening Bone

Objective By prospective randomized controlled double-blind method, before and after treatment on all subjects with clinical symptoms, bone density, calcium, phosphorus, blood alkaline phosphatase, blood lipids, coagulation, liver and kidney function, Double hip MRI and other related indicators were observed to evaluate the clinical effects and adverse reactions about the prevention of glucocorticoid osteoporosis with the therapy of nourishing the kidney and strengthening bone, so we could provide the basis for Chinese medicine treatment.Methods 30 cases of patients with glucocorticold were randomly double blind divided into treatment and control groups by 1:1 ratio. We gave the same basic disease treatment, for all patients with nephrotic syndrome, at the same time, we give bushenjiangu capsule to treatment and placebo to the control group. Through the differences on clinical symptoms, bone density, calcium, phosphorus, blood alkaline phosphatase, blood lipids, coagulation, liver and kidney function (before and after treatment), so we could study the clinical effect on prevention of glucocorticoid osteoporosis with the therapy of nourishing the kidney and strengthening bone, and get an accurate understanding of the best clinical indications and adverse reactions.Results1. After treatment, There was a significant difference on the total effective rate between treatment group (86.67%) and the control group (46.67%) (P<0.05).2. The pain points:The treatment efficacy and Integration of the two groups were significantly improved After treatment, there was significant difference compared with the control group (P< 0.05).3. On the bone mineral density examination: After treatment, the lumbar BMD values of the two groups both increased, there were significant differences compared with before treatment (P< 0.05)and the control group (P<0.05).4. On the Laboratory inspection:After treatment in the treated group, serum calcium scores significantly improved, and serum alkaline phosphatase scores significantly decresed, The change of the treated group was more significant than that of the control group(P<0.05). After treatment, blood cholesterol and serum fibrinogen of the two groups both significantly lower than before treatment, The change of the treated group was more significant than that of the control group(P<0.05).5. The treatment group and control group in liver and kidney function before and after treatment were within the normal range, during the clinical use of the bushenjiangu capsule, some patients Occasionally had adverse reactions, such as sore throat, acne side effects, but no allergies and side effects. Conclusion The therapy of nourishing the kidney and strengthening bone had great impaction on the patients using glucocorticold, bone mineral density could increase, occasionally had adverse reactions, such as sore throat, acne side effects. It indicated that the therapy of TCM had advantage on prevention of glucocorticolds-induced Osteoporosis.