| BackgroundWith the development of society, lifestyle changes, coronary heart disease has become one of the most important cardiovascular diseases. Modern medicine interventions can improve blood lipids in patients with coronary heart disease mortality, morbidity, and related events. Coronary heart disease and damage with TC, LDL-C level was increased. Intensive lipid-lowering therapy is more beneficial than the conventional lipid-lowering therapy. The primary goal of intensive lipid-lowering therapy is to release LDL-C level, but patient tolerance is poor. Finding an effective lipid-lowering, plaque stabilization, clinical curative effect and well tolerated, with fewer symptoms, long-term clinical outcome of coronary heart disease lipid-lowering therapy has become the focus of this study.ObjectStable angina pectoris and spleen lipid transfer excessive care for patients after treatment, the Heart of six different indicators of blood lipid changes, and assess their impact on cardiovascular events and angina symptoms, and to explore the improvement of blood lipids and angina symptoms possible mechanism.MethodsInclusion and exclusion criteria in accordance with Guangdong Provincial Hospital Heart Center selected the branch of a total of 60 patients were treated with randomized double-blind controlled trial,30 patients were randomly divided into treatment and control group of 30 patients, the treatment group and the placebo control group, while to accept Western standards of treatment of angina pectoris, the treatment group to participate in the Treatment of coronary patients in the control group to the placebo treatment for 12 weeks, both groups before and after treatment on fat indexes and angina score, heart Angina attack frequency, duration and pain of the change in the situation were given.Results1. Statistics of age, gender, angina, angina score, NYHA classification, serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (apoAl) and apolipoprotein B (apoB) and other clinical data were not significantly different between two groups (P> 0.05), two groups were comparable.2. Treatment group and control group's Statistics of TC, LDL-C, apoB were significantly improved after treating(P<0.05),The treatment group decreased TC, LDL-C, apoB rate is more obvious than in the control group, there were significant differences between the two groups (P<0.05);Statistics of TG, HDL-C, apoAl in control group were no significant changes (P>0.05). Statistics of HDL-C in Treatment group was higher than before treatment(P<0.05), there is No significant change in TG and apoAl (P>0.05).3. Cardiovascular events in the treatment group and control group, rates were 3.33%and 16.7%after treating, there was significant difference between the two groups (P<0.05); Angina score, angina attack frequency and duration were decreased compared with before treatment in both groups (P<0.05), and the statistics of treatment group was more marked than in the control group, there was significant difference between the two groups (P<0.05). Angina pain has a significantly improvement which was compared with those before treatment. Control group has no significant change in pain(P>0.05).4. There were no significant adverse reactions before and after treatment in both groups.Conclusion1. Participation surgery can significantly improve coronary side serum lipids, particularly in reducing TC, LDL-C, apoB, increased HDL-C, effect is remarkable, long-term use, no significant adverse reactions.2. Based on the standard treatment in Western medicine, patients taking the reference side can be significantly reduced in patients with coronary angina attack frequency, duration of angina pectoris and to improve the degree of pain.3. Lipid disorders can directly affect the prognosis of patients with stable angina pectoris, Dyslipidemia, especially LDL-C, TC is the most important development of coronary heart disease lipid risk factors. Atherosclerotic plaques of cholesterol mainly from LDL, LDL-C can be used as evaluation of the prognosis of patients with stable angina objective material indicators.
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