The Clinical Application Of MR Diffusion Tensor Imaging Diagnosis Cervical Spondylotic Myelopathy In 3.0T

PurposeTo evaluate the application of the diffusion tensor imaging (DTI) as a quantitative tool in cervical spondylotic myelopathy with 3.0T MR.MethodsRoutine MRI and axial DTI were performed in 60 cases of cervical spondylotic myelopathy and 10 cases of healthy volunteers. DTI scanning deploys master single test provoeation-spin echo plane echo imaging sequence. Diffusion weighting coefficient b=800s/mm2; Diffusion saitivity gradient is in thirteen different directions; Revetition time=5000ms, Echo time= 83ms, sheet thickness is 3mm, Sheet interval is 0, Field of view is 18mm×18mm, Collection matrix is 96×96, Collection frequency is 4. According to clinical severity, there were 18 mild,18 moderate,12 severe and 12 serious; According to the type of spinal cord lesion signal,30 cases had no signal abnormality in T1WI and T2WI,19 cases had high signal in T2WI,11 cases had low signal in T1WI, while had high signal in T2WI. GE Functool 4.4 reconstruction package adopted each study the ADC map, FA map,λ1 map,λ2 map,λ3 map. We choose regions of interest at the image of b=0, regions of interest were round or ellipse and size was about 10mm2. The value of ADC, FA,λ1,λ2,λ3 were respectively measured in or near lesions regions, according to the formulaλ⊥= (λ2+λ3)/2 and MD= (λ1+λ2+λ3)/3, calculated the MD values andλ⊥values, respectively. And then compared cases groups to control group in order to observe if difference existed in two groups. We deployed SPSS 13.0 statistical package to carry out statistics analysis and all measurements were demonstrated into mean and standard deviation, Least Significant Difference test(LSD), there exists statistic difference when p<0.05. ResultsImaging of all subjects could clearly display myeloid tissue and there was no evident twist and deform of imaging. In control group, all the values had no statistic difference at each different segment myeloid tissue. Mild group, moderate group, severe group and serious group had statistic differences in the FA values,λ1value,λ⊥value and MD value compared with control group (p<0.05), while ADC value had no statistic differences (p>0.05); N/N group, N/H group and L/H group had statistic differences in the ADC value, FA value andλ⊥. value (p<0.05), whileλ1value and MD value had no statistic differences (p>0.05).ConclusionMagnetic resonance diffusion tensor imaging may be sensitive, accurate and quantitative in evaluation the degree of injury of spinal cord. It can provide valuable information for wallerian degeneration, demyelination and the axonal. It is supplement for conventional MR diagnosis and basis for clinical treatment and prognosis.