Analysis Of Relevant Factors In 70 Cases Of Recurrent Epithelial Ovarian Cancer

Ovarian cancer is one of the most common gynecological malignancies,and 85%-90% of patients are epithetlial ovarian cancer. The early diagnosis is hard to make out beacuase the ovarian is located in the deep of the pelvic cavity,and when you discovered the cancer ,70% of the patients have been to the late stage age.After the surgery and chemotherapy treatments, 50%-80% of the patients recur.It leads to the low 5-year survical rate of the ovarian cancer. Many factors related with ovarian cancer recurrence. Therefore, it has positive significance to make indiidual treatments, improve the prognosis of patients with recurrent, delay time and improve patient surial rates by analysising and summaring these factors with ovarian cancer recurrence relationship. At present, many scholars think there are a few of factors is relevant to the recurrent epithelial ovarian.This research mainly from some aspects to analysis the relationship with the recurrent epithelial oarian cancer,such as clinical parameters of oarian cancer (the age, the clinical stages, residual tumor size, ascites) , pathological parameters (pathologic types, organization classification, lymph node dissection) and adjuvant chemotherapy.Object:Explore the clinical, pathological and adjuvant chemotherapy for I - IV stage solid-cystic-papillary epithelial ovarian cancer patients who have recerived surgery treatment and recur. Method:Retrospective review of 191 patients from the First Hospital of Jilin University with ovarian carcinoma treated surgically between January 2000 and January 2010, and 70 cases are fit for the standard to diagnose recurrent cancer. Using univariate and multivariate analysis method to discussed the various factors of the recurrent epithelial ovarian cancer,such as the clinical stages age, tumor size, ascites, focal residual pathological type, organization classification, lymph node dissection and concomitant treatment.Result:The rate of ovarian cancer recurrence is 36.65%.During the uniariate analysis, age, ascites exfoliated cells and pathologic types, lymph node dissection and chemotherapy pecept are unconcerned with the epithelial ovarian cancer recurrence(P>0.05).The clinical stages, residual tumor size, organization classification,the number of the chemotherapy treatment are relevant with the epithelial ovarian cancer recurrence(P<0.05).During the multiariate analysis, the clinical stages, residual tumor size, organization classification and the number of the chemotherapy treatment are independent factors to influence the patients with recurrent( P<0.05).Other factors are no influence to the recurrent tumor.Conclusion:1. The clinical stages, residual tumor size, organization classification and the number of chemotherapy treatment are relevant factors for epithelial ovarian cancer recurrence.During the multiariate analysis, the clinical stages, residual tumor size, organization classification and the number of chemotherapy treatment are independent factors to influence the patients with recurrent. 2. The later period of the oarian cancer ,the bigger rate of the possibility to recur. Therefore, it is meaningful to improve the prognosis of patients with early diagnosisrate, and decrease the recurrence rate. 3. In patients with adanced oarian cancer, especially the application of combined ascites, neoadjuvant chemotherapy can improve the resection rate, reduce the recurrence rate.4. Age, ascites exfoliated cells ,pathologic types and lymph node dissection and chemotherapy pecept are unconcerned with the epithelial ovarian cancer recurrence.