Investigation Of The Relationship Between Indices Of Metabolic Syndrome And Type 2 Diabetic Retinopathy

AimsTo investigate the association of idices of metabolic syndrome with the occurrence of type 2 diabetic retinopathy in order to find ways to prevent and delay the emergence and increase of diabetic retinopathy.ObjectA retrospective study, which includes 172 cases of clinical active T2DM patients who were hospitalized in department of Endocrinology, Shandong Province Hospital from May,2008 to November,2009. Among them,93 patients were male,79 female, 35 to 80 years old. The average age of the objects was 59.26±10.38 years.MethodsPatients were grouped according to the result of the eyeground photography. Among the total 172 cases,77 were belong to control group (T2DM without diabetic retinopathy group), and the other 99 cases were belong to DR group (T2DM with diabetic retinopathy group). And then compare and analyze the risk factors and prevalence of metabolic syndrome between the two groups. Compare and analyze clinical datas and biochemical characteristics such as age, diabetes duration, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) between the two groups. Then analy the risk factors for DR occurring by use of Logistic Regression Analysis.Results1 Our research showed that the overall prevalence rate of MS in the selected objects was 58.1%(100/172). MS prevalence rates in the Control group and DR group were 49.4%(38/77) and 65.3%(62/95) respectively, and the difference had statistically significant (x2= 4.425, P<0.05).2 DR group's duration was longer than the control group's, which had statistically significant (P<0.01).3 Concentrations of plasma TG and TC in DR group were both higher than that of the control group, which had statistically significant (P<0.05).4 Comparison of the other clinical features and biochemical characteristics between the two groups showed no significant difference in age, SBP, DBP, BMI, HDL-C, LDL-C, FPG or HbA1c, etc (P>0.05).5 The prevalence rates of the 4 risk factors of MS in DR group were all higher than that in the control group, but there was significant only in the hypertension aspect(x2=5.734, P<0.05).6 Multivariate Logistic regression analysis showsed that diabetes duration, concentration of TG were high risk factors for DR occurring (P<0.05).Conclusions1 The prevalence rate of metabolic syndrome (MS) in type 2 diabetic patients was 58.1%(100/172). MS prevalence rates in type 2 diabetic retinopathy patients (65.3%,62/95) was higher than that in simple type 2 diabetes mellitus (49.4%,38/77).2 Compared to simple type 2 diabetes mellitus, there was a longer duration, higher plasma triglycerides and cholesterol levels, higher rates of hypertension in type 2 diabetic retinopathy patients.3 Hypertension, hyperlipidemia which are the risk factors of Metabolic Syndrome, along with a longer duration are the main risk factors for diabetic retinopathy occuring. The occurrence and progression of Diabetic retinopathy is closely related to Metabolic Syndrome and its components.