| Objective To investigate the relationship between metabolic syndrome (MS) and diabetic microangiopathy [including: Early diabetic nephropathy (DN) and diabetic retinopathy (DR)] in type 2 diabetes mellitus (T2DM).Methods A retrospective analysis 453 cases of T2DM who were hospitalized in the First Affiliated Hospital of Guang Xi Medical University from July, 2007 to December, 2007. For 237 cases of T2DM combined with MS, 216 cases of simple T2DM . To compare the incidence of the chronic complications:DN,DR in Each group. All 453 cases were further divided into 5 groups: Simple diabetic Classified as group 1;Containing one other metabolic syndrome components classified as group 2;Containing two other metabolic syndrome components classified as group 3; Containing three other metabolic syndrome components classified as group 4; Containing four other metabolic syndrome components classified as group 5. Further analysis with MS components increased the changes of DN, DR morbidity . And comparative analysis general information of DN,DR such as age, waist circumference(WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), glycosylated hemoglobin (HbA1c), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C ), total cholesterol (TC), triglyceride (TG).Results 1. Research showed that 52.3%(237/453) of T2DM patients have MS at the same time.2. Gender division in the <50-year-old male patients with MS was significantly higher than females, the difference had statistical significance, in patients with≥50-year-old men and women with MS was no significant difference; Age division, <50-year-old and≥50 MS morbidity, There was no significant difference between men ,while the difference had statistical significance in women. (P <0.05).3. The incidence of early DN in T2DM with MS patients (50.2%) was significantly higher than those without MS patients (40.0%) (X2 = 4.471; P = 0.040), and as the MS components increased, The incidence of early DN changed, there was a significant difference ( X2 = 10.261; P = 0.006); The incidence of DR in T2DM with MS patients (32.1%) was significantly higher than those without MS patients (22.7%) ( X2 = 4.979; P = 0.027), and with the MS components increased, The incidence of DR changed, there was a significant difference(X2 =9.015; P = 0.018).4. Multivariate Logistic regression analysis showsed that: SBP, DBP, TG, HbA1c were an high risk factors of early DN happen (P <0 .05); Age, WC, SBP,DBP, TG, HbA1C, LDL were high risk factors for DR occurred (P <0. 05), HDL were protected factors for DR occurred (P <0. 05). Conclusion 1.The incidence of MS in <50-year-old male was significantly higher than <50-year-old female patients; While in≥50-year-old T2DM patients the incidence of MS had no significant differences between men and women.2. MS and early DN and DR is closely related.3. Many components of MS involved in the pathogenesis of DN and DR process. |
