Expression And Significance Of Estrogen Receptor,Progesterone Receptor And P53 In Endometrial Carcinoma

ObjectiveTo investigate the expression and clinical significance of estrogen receptor(ER), progesterone receptor(PR)and P53 in endometrial carcinoma.MethodsBetween Jan 1st,2005 and Jan 1st,2010, inpatients diagnosised as endometrial carcinomar after surgery in Shandong Provincial Hospital were collected with the aid of computed case system,and 197 cases were selected as objectives according to the criteria,detailed records of patients' pathological diagnostic information, including histological type, histological grade, myometrial invasion,lymph node metastasis and immunohistochemical detection of endometrial carcinoma ER, PR, P53 and to analyze its expression and relationship and clinical significance with histological type, histological grade, surgical stage, myometrial invasion and lymph node metastasis in the endometrial carcinoma. Microsoft Excel 2003 was applied to set the data and statistical analysis was done by SPSS 17.0.Results1.ER, PR, P53 in endometrial carcinoma, the positive expression rate was 69.0%, 72.6% and 23.4%.2.171 patients of type-Ⅰendometrial cancer, ER and PR positive expression rate in medium and low histological grade group (G1+G2)(87.5%,84.7%)was significantly higher than the group with high histological grade(G3)(55.6%,63%), and the difference was statistically significant (P＜0.001).3.With the increase of pathological stage, ER, PR positive expression rate decreased, P53 positive rate increased gradually, through statistical analysis, PR and P53 expression had statistically significance.4. Myometrial invasion> 1/2 cases group,ER and PR was lower than the depth of myometrial invasion≤1/2 case group, the difference was statistically significant (P<0.05); P53 positive rate in myometrial invasion>1/2 group (30.2%) was higher than myometrial invasion≤1/2 group (13.9%), the difference was also statistically significant (P<0.01).5.P53 positive expression rates with lymph node metastasis group (69.2%) was much higher than lymph node-negative group (18.1%), with the difference statistically significant (P＜0.001).6.ER and PR positive rate of type-I EC (76.6%,81.3%) was significantly higher than in type-II EC (19.2%,15.4%), the difference was statistically significant (P <0.01); P53 positive rate in type-II EC (61.5%) was significantly higher than theⅠ-type EC (17.5%), the difference was statistically significant (P<0.01).Conclusions1.ER, PR positive rate in Endometrial carcinoma was a negative correlation with histological grade, myometrial invasion, ie the higher of ER, PR positive rate,the better of tumor differentiation, the more superficial of myometrial invasion; PR expression was negatively related to surgical stage, the more advanced cases, the lower rates of PR expression; and closely related to tumor histological type, that is ER, PR positive rate in I-tppe EC is much higher than II-type EC; Patients with a higher ER, PR positive rate will have a better prognosis.2.P53 positive rate in endometrial carcinoma was a positive correlation with histological grade, surgical stage, myometrial invasion, lymph node metastasis,poorer differentiation, higher pathological stage, deeper myometrial invasion, lymph node metastasis accompanied with higher P53 positive rate; and closely related to histological type, P53 positive rate inⅠ-type EC was far lower than II-type EC; Therefore, P53 can be considered as a invasive progress mark of endometrial carcinoma,which positive expression suggest a poorer prognosis for patients, especially more meaningful for type-ⅡEC. 3.ER, PR and P53 play important roles in the development of endometrial carcinoma.Patients with. endometrial carcinoma should undergo immunohistochemical detection of ER, PR, P53, and thus betterly and comprehensively evaluating prognosis and treatment of patients.